Cell-associated HIV RNA: a dynamic biomarker of viral persistence

被引：105

作者：

Pasternak, Alexander O. ^{[1
]}

Lukashov, Vladimir V. ^{[1
]}

Berkhout, Ben ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Ctr Infect & Immun Amsterdam CINIMA, Dept Med Microbiol,Lab Expt Virol, NL-1105 AZ Amsterdam, Netherlands

来源：

RETROVIROLOGY | 2013年 / 10卷

关键词：

Cell-associated HIV RNA; Virological biomarker; HIV-1; persistence; reservoir; Antiretroviral therapy; HIV cure; IMMUNODEFICIENCY-VIRUS TYPE-1; REAL-TIME PCR; ACTIVE ANTIRETROVIRAL THERAPY; BLOOD MONONUCLEAR-CELLS; LOW-LEVEL VIREMIA; CD4(+) T-CELLS; COURSE RALTEGRAVIR INTENSIFICATION; HIGHLY SENSITIVE METHODS; IN-SITU HYBRIDIZATION; MESSENGER-RNA;

D O I：

10.1186/1742-4690-10-41

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In most HIV-infected individuals adherent to modern antiretroviral therapy (ART), plasma viremia stays undetectable by clinical assays and therefore, additional virological markers for monitoring and predicting therapy responses and for measuring the degree of HIV persistence in patients on ART should be identified. For the above purposes, quantitation of cell-associated HIV biomarkers could provide a useful alternative to measurements of viral RNA in plasma. This review concentrates on cell-associated (CA) HIV RNA with the emphasis on its use as a virological biomarker. We discuss the significance of CA HIV RNA as a prognostic marker of disease progression in untreated patients and as an indicator of residual virus replication and the size of the dynamic viral reservoir in ART-treated patients. Potential value

引用

页数：15

共 167 条

[31] ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS-INFECTED TISSUES BY AMPLIFICATION AND INSITU HYBRIDIZATION REVEALS LATENT AND PERMISSIVE INFECTIONS AT SINGLE-CELL RESOLUTION [J].