Enhancement of hematopoietic stem cell engraftment by inhibition of CXCL12 proteolysis with sitagliptin, an oral dipeptidyl-peptidase IV inhibitor: A report in a case of delayed graft failure

被引:6
作者
Focosi, Daniele [1 ]
Kast, Richard Eric [2 ]
Metelli, Maria Rita [3 ]
Benedetti, Edoardo [1 ]
Galimberti, Sara [1 ]
Papineschi, Federico [1 ]
Petrini, Mario [1 ]
机构
[1] Univ Santa Chiara, Azienda Osped, Div Hematol, I-56100 Pisa, Italy
[2] Univ Vermont, Dept Psychiat, Burlington, VT 05401 USA
[3] Univ Santa Chiara, Azienda Osped, Dept Lab Med, I-56100 Pisa, Italy
关键词
BONE-MARROW-TRANSPLANTATION; HEMOPHAGOCYTIC SYNDROME; ALLOGENEIC TRANSPLANTATION; CD26; INFECTION; INFUSION;
D O I
10.1016/j.leukres.2008.04.019
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:178 / 181
页数:4
相关论文
共 22 条
[1]  
Augustyns K, 1999, CURR MED CHEM, V6, P311
[2]   G-CSF- and GM-CSF-induced upregulation of CD26 peptidase downregulates the functional chemotactic response of CD34+CD38- human cord blood hematopoietic cells [J].
Christopherson, Kent W., II ;
Uralil, Sherene E. ;
Porecha, Nehal K. ;
Zabriskie, Ryan C. ;
Kidd, Shannon M. ;
Ramin, Susan M. .
EXPERIMENTAL HEMATOLOGY, 2006, 34 (08) :1060-1068
[3]   Modulation of hematopoietic stem cell homing and engraftment by CD26 [J].
Christopherson, KW ;
Hangoc, G ;
Mantel, CR ;
Broxmeyer, HE .
SCIENCE, 2004, 305 (5686) :1000-1003
[4]   Cell surface peptidase CD26/dipeptidylpeptidase IV regulates CXCL12/stromal cell-derived factor-1α-mediated chemotaxis of human cord blood CD34+ progenitor cells [J].
Christopherson, KW ;
Hangoc, G ;
Broxmeyer, HE .
JOURNAL OF IMMUNOLOGY, 2002, 169 (12) :7000-7008
[5]  
DAVIES SM, 1994, BONE MARROW TRANSPL, V14, P73
[6]  
Focosi D, 2007, LANCET, V369, P269, DOI 10.1016/S0140-6736(07)60137-8
[7]   Graft failure due to hemophagocytic syndrome after autologous peripheral blood stem cell transplantation [J].
Fukuno, K ;
Tsurumi, H ;
Yamada, T ;
Oyama, M ;
Moriwaki, H .
INTERNATIONAL JOURNAL OF HEMATOLOGY, 2001, 73 (02) :262-265
[8]   Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1 [J].
Green, Brian D. ;
Irwin, Nigel ;
Duffy, Nicola A. ;
Gault, Victor A. ;
O'Harte, Finbarr P. M. ;
Flatt, Peter R. .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 547 (1-3) :192-199
[9]   Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: Focus on sitagliptin [J].
Herman, G. A. ;
Stein, P. P. ;
Thornberry, N. A. ;
Wagner, J. A. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2007, 81 (05) :761-767
[10]   Inhibition of the activity of dipeptidyl peptidase IV as a treatment for type 2 diabetes [J].
Holst, JJ ;
Deacon, CF .
DIABETES, 1998, 47 (11) :1663-1670