Ethanol-induced behavioral sensitization is associated with dopamine receptor changes in the mouse olfactory tubercle

被引:32
作者
de Araujo, Nilza Pereira [1 ]
Fukushiro, Daniela Fukue [1 ]
Grassi, Christian [1 ]
Hipolide, Debora C. [2 ]
Souza-Formigoni, Maria Lucia O. [2 ]
Tufik, Sergio [2 ]
Frussa-Filho, Roberto [1 ]
机构
[1] Univ Fed Sao Paulo, Dept Farmacol, BR-04023062 Sao Paulo, Brazil
[2] Univ Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo, Brazil
基金
巴西圣保罗研究基金会;
关键词
Behavioral sensitization; D2; binding; Ethanol; Olfactory tubercle; VENTRAL TEGMENTAL AREA; RECOMBINANT INBRED MICE; RAT NUCLEUS-ACCUMBENS; SOCIAL DEFEAT STRESS; LOCOMOTOR-ACTIVITY; COCAINE SENSITIZATION; MESOLIMBIC DOPAMINE; FEMALE RATS; STEREOTYPED BEHAVIOR; ROTATIONAL BEHAVIOR;
D O I
10.1016/j.physbeh.2008.07.029
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Accumulating evidence points to the mesolimbic and the nigrostriatal dopamine systems as critical to behavioral sensitization induced by several drugs of abuse. In the present study, we analyzed D1 and D2 binding to brain regions related to these dopaminergic systems during the expression of ethanol-induced behavioral sensitization. The first experiment was performed to demonstrate the effectiveness of the ethanol treatment schedule and challenge used to induce the expression of the behavioral sensitization phenomenon. The second experiment was conducted to study D1 and D2 alterations in several brain regions during the expression of this phenomenon. Mice were ip treated with ethanol or saline for 21 consecutive days and 24 It after the last injection they received an ethanol or a saline challenge injection. Five minutes later, the animals were observed in an open-field for locomotion quantification or were sacrificed and their brains were submitted to autoradiographic binding analyses. No differences among the groups were found for D1 binding levels in all the brain regions analyzed. However, ethanol-sensitized mice showed reduced levels of D2 binding in the olfactory tubercle when compared to the other groups. Our data suggest that D2 receptor changes in the olfactory tubercle seem to play an important role in the expression of ethanol-induced behavioral sensitization. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:12 / 17
页数:6
相关论文
共 79 条
[1]  
ALVAREZ JN, 2006, PHARM BIOCH BEHAV, V83, P500, DOI DOI 10.1016/J.PBB.2006.03.010
[2]  
[Anonymous], BRAIN RES
[3]   Drug-induced home cage conspecifics' behavior can potentiate behavioral sensitization in mice [J].
Araujo, N. P. ;
Fukushiro, D. F. ;
Cunha, J. L. S. ;
Levin, R. ;
Chinen, C. C. ;
Carvalho, R. C. ;
Ribeiro, I. C. P. ;
Gomes, D. C. ;
Abilio, V. C. ;
Silva, R. H. ;
Ribeiro, R. de A. ;
Frussa-Filho, R. .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2006, 84 (01) :142-147
[4]   Sleep deprivation abolishes the locomotor stimulant effect of ethanol in mice [J].
Araujo, NP ;
Andersen, ML ;
Abílio, VC ;
Gomes, DC ;
Carvalho, RC ;
Silva, RH ;
Ribeiro, RD ;
Tufik, S ;
Frussa, R .
BRAIN RESEARCH BULLETIN, 2006, 69 (03) :332-337
[5]   The importance of housing conditions on behavioral sensitization and tolerance to ethanol [J].
Araujo, NP ;
Camarini, R ;
Souza-Formigoni, MLO ;
Carvalho, RC ;
Abílio, VC ;
Silva, RH ;
Ricardo, VP ;
Ribeiro, RD ;
Frussa-Filho, R .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2005, 82 (01) :40-45
[6]   Alterations in mesolimbic dopamine function during the abstinence period following chronic ethanol consumption [J].
Bailey, CP ;
O'Callaghan, MJ ;
Croft, AP ;
Manley, SJ ;
Little, HJ .
NEUROPHARMACOLOGY, 2001, 41 (08) :989-999
[7]   D1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement [J].
Bari, AA ;
Pierce, RC .
NEUROSCIENCE, 2005, 135 (03) :959-968
[8]   Monosialoganglioside attenuates the excitatory and behavioural sensitization effects of ethanol [J].
Bellot, RG ;
Camarini, R ;
Vital, MABF ;
PalermoNeto, J ;
Leyton, V ;
Frussa, R .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 313 (03) :175-179
[9]   Ethanol directly excites dopaminergic ventral tegmental area reward neurons [J].
Brodie, MS ;
Pesold, C ;
Appel, SB .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1999, 23 (11) :1848-1852
[10]   ETHANOL INCREASES THE FIRING RATE OF DOPAMINE NEURONS OF THE RAT VENTRAL TEGMENTAL AREA INVITRO [J].
BRODIE, MS ;
SHEFNER, SA ;
DUNWIDDIE, TV .
BRAIN RESEARCH, 1990, 508 (01) :65-69