Ethanol-induced behavioral sensitization is associated with dopamine receptor changes in the mouse olfactory tubercle

被引:32
作者
de Araujo, Nilza Pereira [1 ]
Fukushiro, Daniela Fukue [1 ]
Grassi, Christian [1 ]
Hipolide, Debora C. [2 ]
Souza-Formigoni, Maria Lucia O. [2 ]
Tufik, Sergio [2 ]
Frussa-Filho, Roberto [1 ]
机构
[1] Univ Fed Sao Paulo, Dept Farmacol, BR-04023062 Sao Paulo, Brazil
[2] Univ Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo, Brazil
基金
巴西圣保罗研究基金会;
关键词
Behavioral sensitization; D2; binding; Ethanol; Olfactory tubercle; VENTRAL TEGMENTAL AREA; RECOMBINANT INBRED MICE; RAT NUCLEUS-ACCUMBENS; SOCIAL DEFEAT STRESS; LOCOMOTOR-ACTIVITY; COCAINE SENSITIZATION; MESOLIMBIC DOPAMINE; FEMALE RATS; STEREOTYPED BEHAVIOR; ROTATIONAL BEHAVIOR;
D O I
10.1016/j.physbeh.2008.07.029
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Accumulating evidence points to the mesolimbic and the nigrostriatal dopamine systems as critical to behavioral sensitization induced by several drugs of abuse. In the present study, we analyzed D1 and D2 binding to brain regions related to these dopaminergic systems during the expression of ethanol-induced behavioral sensitization. The first experiment was performed to demonstrate the effectiveness of the ethanol treatment schedule and challenge used to induce the expression of the behavioral sensitization phenomenon. The second experiment was conducted to study D1 and D2 alterations in several brain regions during the expression of this phenomenon. Mice were ip treated with ethanol or saline for 21 consecutive days and 24 It after the last injection they received an ethanol or a saline challenge injection. Five minutes later, the animals were observed in an open-field for locomotion quantification or were sacrificed and their brains were submitted to autoradiographic binding analyses. No differences among the groups were found for D1 binding levels in all the brain regions analyzed. However, ethanol-sensitized mice showed reduced levels of D2 binding in the olfactory tubercle when compared to the other groups. Our data suggest that D2 receptor changes in the olfactory tubercle seem to play an important role in the expression of ethanol-induced behavioral sensitization. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:12 / 17
页数:6
相关论文
共 79 条
[61]  
Robinson DL, 2002, ALCOHOL CLIN EXP RES, V26, P165, DOI 10.1097/00000374-200202000-00003
[62]   BEHAVIORAL SENSITIZATION - CHARACTERIZATION OF ENDURING CHANGES IN ROTATIONAL BEHAVIOR PRODUCED BY INTERMITTENT INJECTIONS OF AMPHETAMINE IN MALE AND FEMALE RATS [J].
ROBINSON, TE .
PSYCHOPHARMACOLOGY, 1984, 84 (04) :466-475
[63]   THE NEURAL BASIS OF DRUG CRAVING - AN INCENTIVE-SENSITIZATION THEORY OF ADDICTION [J].
ROBINSON, TE ;
BERRIDGE, KC .
BRAIN RESEARCH REVIEWS, 1993, 18 (03) :247-291
[64]   SENSITIZATION TO STRESS - THE ENDURING EFFECTS OF PRIOR STRESS ON AMPHETAMINE-INDUCED ROTATIONAL BEHAVIOR [J].
ROBINSON, TE ;
ANGUS, AL ;
BECKER, JB .
LIFE SCIENCES, 1985, 37 (11) :1039-1042
[65]   Regional heterogeneity for the intracranial self-administration of ethanol within the ventral tegmental area of female Wistar rats [J].
Rodd-Henricks, ZA ;
McKinzie, DL ;
Crile, RS ;
Murphy, JM ;
McBride, WJ .
PSYCHOPHARMACOLOGY, 2000, 149 (03) :217-224
[66]   A COUPLED-OSCILLATOR MODEL OF OVARIAN-CYCLE SYNCHRONY AMONG FEMALE RATS [J].
SCHANK, JC ;
MCCLINTOCK, MK .
JOURNAL OF THEORETICAL BIOLOGY, 1992, 157 (03) :317-362
[67]  
SEGAL DS, 1979, CATECHOLAMINES BASIC, V2, P1672
[68]   Intracranial self-administration of MDMA into the ventral striatum of the rat: differential roles of the nucleus accumbens shell, core, and olfactory tubercle [J].
Shin, Rick ;
Qin, Mei ;
Liu, Zhong-Hua ;
Ikemoto, Satoshi .
PSYCHOPHARMACOLOGY, 2008, 198 (02) :261-270
[69]   Sensitization to ethanol's stimulant effect is associated with region-specific increases in brain D2 receptor binding [J].
Souza-Formigoni, MLO ;
De Lucca, EM ;
Hipólide, DC ;
Enns, SC ;
Oliveira, MGM ;
Nobrega, JN .
PSYCHOPHARMACOLOGY, 1999, 146 (03) :262-267
[70]   Flupenthixol as a potential pharmacotreatment of alcohol and cocaine abuse/dependence [J].
Soyka, M ;
De Vry, J .
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2000, 10 (05) :325-332