Vascular endothelial growth factor in the lung

被引：319

作者：

Voelkel, NF

Vandivier, RW

Tuder, RM

机构：

[1] Univ Colorado, Hlth Sci Ctr, Div Pulm & Crit Care, Denver, CO USA

[2] Johns Hopkins Univ, Div Cardiopulm Pathol, Baltimore, MD USA

[3] Johns Hopkins Univ, Div Pulm & Crit Care Med, Baltimore, MD USA

[4] Johns Hopkins Univ, Dept Pathol, Baltimore, MD USA

[5] Johns Hopkins Univ, Dept Med, Baltimore, MD USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 2006年 / 290卷 / 02期

关键词：

D O I：

10.1152/ajplung.00185.2005

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Vascular endothelial growth factor (VEGF) is a pluripotent growth and permeability factor that has a broad impact on endothelial cell function. The lung tissue is very rich in this protein; many different lung cells produce VEGF and also respond to VEGF. VEGF is critical for the development of the lung and serves as a maintenance factor during adult life. In addition to the physiological functions of this protein, there is increasing evidence that VEGF also plays a role in several acute and chronic lung diseases, such as acute lung injury, severe pulmonary hypertension, and emphysema. Here we provide a comprehensive overview of the rapidly expanding literature.

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页码：L209 / L221

页数：13

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