Management of cerebral metastases from malignant melanoma: Results of a combined, simultaneous treatment with fotemustine and irradiation

被引:18
作者
Ulrich, J
Gademann, G
Gollnick, H
机构
[1] Otto von Guericke Univ, Sch Med, Dept Dermatol & Venereol, Oncol Unit, D-39120 Magdeburg, Germany
[2] Otto von Guericke Univ, Sch Med, Dept Radiotherapy, D-39120 Magdeburg, Germany
关键词
malignant melanoma; brain metastases; chemotherapy; fotemustine; DTIC; radiation therapy;
D O I
10.1023/A:1006280304912
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We report results of a conservative treatment for brain metastases from malignant melanoma with a combination of irradiation and chemotherapy (fotemustine and/or DTIC). To date, 12 patients have been treated. There was a complete remission of the brain metastases in four patients. In two patients a partial remission was observed. The mean survival of the responder was 8.2 months (95% confidence interval 3.8-12.6 months). The most common side effects were thrombocytopenia, leukopenia, and alopecia. Altogether, the treatment was well tolerated. As the outcome of patients with brain metastases from malignant melanoma is generally poor, this combined chemo- and radiation therapy may provide improved care for such patients.
引用
收藏
页码:173 / 178
页数:6
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