Transcriptional regulation of IL-2 in health and autoimmunity

被引：78

作者：

Crispin, Jose C. ^{[1
]}

Tsokos, George C. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USA

来源：

AUTOIMMUNITY REVIEWS | 2009年 / 8卷 / 03期

关键词：

Chromatin remodeling; FoxP3; IL-2; Systemic lupus erythematosus; Transcriptional regulation; SYSTEMIC-LUPUS-ERYTHEMATOSUS; RESPONSE ELEMENT MODULATOR; T-CELL FUNCTION; INTERLEUKIN-2 GENE PROMOTER; IL2; GENE; HISTONE ACETYLATION; BINDING PROTEIN; EXPRESSION; FOXP3; LYMPHOCYTES;

D O I：

10.1016/j.autrev.2008.07.042

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The regulation of IL-2 production is central to our understanding of the immune system. Key during T cell activation, it also plays an essential role in the regulation of the immune response. This review discusses the function of recently described factors that modulate transcription and chromatin remodeling at the IL2 promoter. Also, it addresses the role of FoxP3 as a transcriptional regulator in conventional T cells and regulatory T cells, and the mechanisms whereby CD28 stabilizes IL2 transcription and translation. Finally, the alterations that prevent T cells from SLE patients from producing normal amounts of IL-2 upon stimulation are described. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：190 / 195

页数：6

共 40 条

[1] Cell-type-specific epigenetic marking of the IL2 gene at a distal cis-regulatory region in competent, nontranscribing T-cells [J].

Adachi, S ;

Rothenberg, EV .

NUCLEIC ACIDS RESEARCH, 2005, 33 (10) :3200-3210

[2] Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production [J].

Allan, Sarah E. ;

Crome, Sarah Q. ;

Crellin, Natasha K. ;

Passerini, Laura ;

Steiner, Theodore S. ;

Bacchetta, Rosa ;

Roncarolo, Maria G. ;

Levings, Megan K. .

INTERNATIONAL IMMUNOLOGY, 2007, 19 (04) :345-354

[3] Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells [J].

Bandyopadhyay, Sanmay ;

Dure, Myrianne ;

Paroder, Monika ;

Soto-Nieves, Noemi ;

Puga, Irene ;

Macian, Fernando .

BLOOD, 2007, 109 (07) :2878-2886

[4] Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process [J].

Bruniquel, D ;

Schwartz, RH .

NATURE IMMUNOLOGY, 2003, 4 (03) :235-240

[5] BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses [J].

Brunner, Cornelia ;

Sindrilaru, Anca ;

Girkontaite, Irute ;

Fischer, Klaus-Dieter ;

Tter, Cord Sunderko ;

Wirth, Thomas .

EMBO JOURNAL, 2007, 26 (13) :3191-3202

[6] Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation [J].

Chen, Chunxia ;

Rowell, Emily A. ;

Thomas, Rajan M. ;

Hancock, Wayne W. ;

Wells, Andrew D. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (48) :36828-36834

[7] BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes [J].

Cismasiu, Valeriu B. ;

Ghanta, Sailaja ;

Duque, Javier ;

Albu, Diana I. ;

Chen, Hong-Mei ;

Kasturi, Rohini ;

Avram, Dorina .

BLOOD, 2006, 108 (08) :2695-2702

[8] Cutting edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription [J].

Collins, Samuel ;

Wolfraim, Lawrence A. ;

Drake, Charles G. ;

Horton, Maureen R. ;

Powell, Jonathan D. .

JOURNAL OF IMMUNOLOGY, 2006, 177 (12) :8301-8305

[9] Novel molecular targets in the treatment of systemic lupus erythematosus [J].

Crispin, Jose C. ;

Tsokos, George C. .

AUTOIMMUNITY REVIEWS, 2008, 7 (03) :256-261

[10] Foxp3-dependent programme of regulatory T-cell differentiation [J].

Gavin, Marc A. ;

Rasmussen, Jeffrey P. ;

Fontenot, Jason D. ;

Vasta, Valeria ;

Manganiello, Vincent C. ;

Beavo, Joseph A. ;

Rudensky, Alexander Y. .

NATURE, 2007, 445 (7129) :771-775

← 1 2 3 4 →