Transcriptional regulation of IL-2 in health and autoimmunity
被引:78
作者:
Crispin, Jose C.
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Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USAHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USA
Crispin, Jose C.
[1
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Tsokos, George C.
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Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USAHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USA
Tsokos, George C.
[1
]
机构:
[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USA
The regulation of IL-2 production is central to our understanding of the immune system. Key during T cell activation, it also plays an essential role in the regulation of the immune response. This review discusses the function of recently described factors that modulate transcription and chromatin remodeling at the IL2 promoter. Also, it addresses the role of FoxP3 as a transcriptional regulator in conventional T cells and regulatory T cells, and the mechanisms whereby CD28 stabilizes IL2 transcription and translation. Finally, the alterations that prevent T cells from SLE patients from producing normal amounts of IL-2 upon stimulation are described. (c) 2008 Elsevier B.V. All rights reserved.
机构:
Univ Calif San Francisco, Biomed Sci Program, Dept Med, San Francisco, CA 94143 USAUniv Calif San Francisco, Biomed Sci Program, Dept Med, San Francisco, CA 94143 USA
Ma, Averil
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Koka, Rima
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Univ Calif San Francisco, Biomed Sci Program, Dept Med, San Francisco, CA 94143 USAUniv Calif San Francisco, Biomed Sci Program, Dept Med, San Francisco, CA 94143 USA
Koka, Rima
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Burkett, Patrick
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Univ Calif San Francisco, Biomed Sci Program, Dept Med, San Francisco, CA 94143 USAUniv Calif San Francisco, Biomed Sci Program, Dept Med, San Francisco, CA 94143 USA
机构:
Univ Calif San Francisco, Biomed Sci Program, Dept Med, San Francisco, CA 94143 USAUniv Calif San Francisco, Biomed Sci Program, Dept Med, San Francisco, CA 94143 USA
Ma, Averil
;
Koka, Rima
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h-index: 0
机构:
Univ Calif San Francisco, Biomed Sci Program, Dept Med, San Francisco, CA 94143 USAUniv Calif San Francisco, Biomed Sci Program, Dept Med, San Francisco, CA 94143 USA
Koka, Rima
;
Burkett, Patrick
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h-index: 0
机构:
Univ Calif San Francisco, Biomed Sci Program, Dept Med, San Francisco, CA 94143 USAUniv Calif San Francisco, Biomed Sci Program, Dept Med, San Francisco, CA 94143 USA