Transcriptional regulation of IL-2 in health and autoimmunity

被引:78
作者
Crispin, Jose C. [1 ]
Tsokos, George C. [1 ]
机构
[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USA
关键词
Chromatin remodeling; FoxP3; IL-2; Systemic lupus erythematosus; Transcriptional regulation; SYSTEMIC-LUPUS-ERYTHEMATOSUS; RESPONSE ELEMENT MODULATOR; T-CELL FUNCTION; INTERLEUKIN-2 GENE PROMOTER; IL2; GENE; HISTONE ACETYLATION; BINDING PROTEIN; EXPRESSION; FOXP3; LYMPHOCYTES;
D O I
10.1016/j.autrev.2008.07.042
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The regulation of IL-2 production is central to our understanding of the immune system. Key during T cell activation, it also plays an essential role in the regulation of the immune response. This review discusses the function of recently described factors that modulate transcription and chromatin remodeling at the IL2 promoter. Also, it addresses the role of FoxP3 as a transcriptional regulator in conventional T cells and regulatory T cells, and the mechanisms whereby CD28 stabilizes IL2 transcription and translation. Finally, the alterations that prevent T cells from SLE patients from producing normal amounts of IL-2 upon stimulation are described. (c) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:190 / 195
页数:6
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