Ventilator-Induced Lung Injury: Minimizing Its Impact in Patients With or at Risk for ARDS

被引：40

作者：

Biehl, Michelle ^{[1
,2
]}

Kashiouris, Markos G. ^{[1
,2
]}

Gajic, Ognjen ^{[1
,2
]}

机构：

[1] Mayo Clin, Div Pulm & Crit Care, Rochester, MN 55905 USA

[2] Mayo Clin, Rochester, MN 55905 USA

来源：

RESPIRATORY CARE | 2013年 / 58卷 / 06期

关键词：

ARDS; ventilator-induced lung injury; VILI; tidal volume; mechanical ventilation; prevention; RESPIRATORY-DISTRESS-SYNDROME; END-EXPIRATORY PRESSURE; TIDAL VOLUME VENTILATION; PROTECTIVE-VENTILATION; ALVEOLAR RECRUITMENT; MECHANICAL VENTILATION; ARTERIAL OXYGENATION; PULMONARY; STRATEGY; ATELECTASIS;

D O I：

10.4187/respcare.02347

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Ventilator-induced lung injury (VILI) results from injury to the blood-gas barrier caused by mechanical ventilation. The determinants of VILI are more complex than originally thought, and include the nature, duration, and intensity of the exposure, as well the pattern of initial insult to the lung. Lung-protective mechanical ventilation founded on these basic principles resulted in improved hospital and long-term mortality. The purpose of this review is to provide a comprehensive assessment of the pathogenesis of VILI and its determinants. We also discuss the best preventive approach in patients with or at risk for ARDS and critically appraise the most recent evidence, expert opinion, and implementation of the acquired knowledge to the bedside. (C) 2013 Daedalus Enterprises

引用

页码：927 / 934

页数：8

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