Gene Unscrambler for detangling scrambled genes in ciliates

被引:8
作者
Cavalcanti, ARO [1 ]
Landweber, LF [1 ]
机构
[1] Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA
关键词
D O I
10.1093/bioinformatics/bth003
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Summary: Scrambled genes are surprisingly common in some species of ciliates. Until now there was no software available to analyze automatically these genes. We present here a program that can automatically align the macronuclear and micronuclear forms of a gene, outputting the location of the macronuclear destined segments and pointer sequences.
引用
收藏
页码:800 / U778
页数:11
相关论文
共 6 条
[1]   Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].
Altschul, SF ;
Madden, TL ;
Schaffer, AA ;
Zhang, JH ;
Zhang, Z ;
Miller, W ;
Lipman, DJ .
NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402
[2]   SCRAMBLING OF THE ACTIN I GENE IN 2 OXYTRICHA SPECIES [J].
DUBOIS, M ;
PRESCOTT, DM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (09) :3888-3892
[3]   Evolution and assembly of an extremely scrambled gene [J].
Landweber, LF ;
Kuo, TC ;
Curtis, EA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3298-3303
[4]   Second round of gene sequencing goes down to the farm [J].
Powell, K .
NATURE, 2002, 419 (6904) :237-237
[5]   Genome gymnastics: Unique modes of DNA evolution and processing in ciliates [J].
Prescott, DM .
NATURE REVIEWS GENETICS, 2000, 1 (03) :191-198
[6]   THE DNA OF CILIATED PROTOZOA [J].
PRESCOTT, DM .
MICROBIOLOGICAL REVIEWS, 1994, 58 (02) :233-267