First clinical experience with ADEPT

被引：31

作者：

Bagshawe, KD

Begent, RHJ

机构：

[1] Department of Clinical Oncology, Roy. Free Hosp. School of Medicine

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1996年 / 22卷 / 03期

关键词：

D O I：

10.1016/S0169-409X(96)00443-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The several agents used in the ADEPT approach interact in vivo and it seemed possible that the translation from mouse to man might identify new and unanticipated problems. In taking novel agents into the clinic, the purpose was to test the general feasibility of the ADEPT concept, to identify problems that had not been identified in the mouse, to test the potential of an immunosuppressive agent to allow more than one cycle of therapy to be given and, if possible to demonstrate efficacy. The first pilot-scale trial was carried out at Charing Cross Hospital between 1990-1992.

引用

页码：365 / 367

页数：3

共 7 条

[1]

Bagshawe K.D., 1995, TUMOUR TARGETING, V1, P17

[2] ACCURATE QUANTIFICATION OF I-131 DISTRIBUTION BY GAMMA-CAMERA IMAGING [J].