Genital HSV-2 Infection Induces Short-Term NK Cell Memory

被引：70

作者：

Abdul-Careem, Mohamed F. ^{[1
,2
]}

Lee, Amanda J. ^{[1
,2
]}

Pek, Elishka A. ^{[1
,2
]}

Gill, Navkiran ^{[1
,2
]}

Gillgrass, Amy E. ^{[1
,2
]}

Chew, Marianne V. ^{[1
,2
]}

Reid, Sarah ^{[1
,2
]}

Ashkar, Ali A. ^{[1
,2
]}

机构：

[1] McMaster Univ, McMaster Immunol Res Ctr, Hamilton, ON, Canada

[2] McMaster Univ, Inst Infect Dis Res, Dept Pathol & Mol Med, McMaster Univ Hlth Sci Ctr, Hamilton, ON, Canada

来源：

PLOS ONE | 2012年 / 7卷 / 03期

基金：

加拿大健康研究院;

关键词：

NATURAL-KILLER-CELLS; SIMPLEX-VIRUS TYPE-2; ADAPTIVE IMMUNITY; INNATE; MICE; RESPONSES; VACCINATION; INTERFERON; PROTECTION; INDUCTION;

D O I：

10.1371/journal.pone.0032821

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

NK cells are known as innate immune cells that lack immunological memory. Recently, it has been shown that NK cells remember encounters with chemical haptens that induce contact hypersensitivity and cytomegalovirus infection. Here, we show the existence of NK cell memory following HSV-2 infection. Stimulation with HSV-2 Ags led to higher IFN gamma production in NK cells that were exposed 30 days previously to HSV-2, compared to NK cells from naive mice. More importantly, this increased production of IFN gamma in NK cells was independent of B- and T-lymphocytes and specific for the HSV-2 Ags. We also showed that previously exposed NK cells in a B- and T-lymphocyte free environment mediate protection against HSV-2 infection and they are necessary for the protection of mice against HSV-2 infection. Collectively, NK cells remember prior HSV-2 encounters independent of B- and T-lymphocytes leading to protection against HSV-2 mediated morbidity and mortality upon re-exposure.

引用

页数：10

共 23 条

[21] Adaptive immune features of natural killer cells [J].