The origin and phylogeography of dog rabies virus

被引:173
作者
Bourhy, Herve [1 ]
Reynes, Jean-Marc [2 ]
Dunham, Eleca J. [3 ]
Dacheux, Laurent [1 ]
Larrous, Florence [1 ]
Huong, Vu Thi Oue [4 ]
Xu, Gelin
Yan, Jiaxin
Miranda, Mary Elizabeth G. [5 ]
Holmes, Edward C. [3 ,6 ]
机构
[1] Inst Pasteur, WHO, Collaborating Ctr Reference & Res Rabies, UPRE Lyssavirus Dynam & Host Adaptat, F-75724 Paris 15, France
[2] Inst Pasteur Cambodia, Phnom Penh, Cambodia
[3] Penn State Univ, Mueller Lab, Dept Biol, Ctr Infect Dis Dynam, University Pk, PA 16802 USA
[4] Inst Pasteur Ho Chi Minh City, Ho Chi Minh City, Vietnam
[5] Res Inst Trop Med, Vet Res Dept, Manila, Philippines
[6] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA
关键词
D O I
10.1099/vir.0.2008/003913-0
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Rabies is a progressively fatal and incurable viral encephalitis caused by a lyssavirus infection. Almost all of the 55 000 annual rabies deaths in humans result from infection with dog rabies viruses (RABV). Despite the importance of rabies for human health, little is known about the spread of RABV in dog populations, and patterns of biodiversity have only been studied in limited geographical space. To address these questions on a global scale, we sequenced 62 new isolates and performed an extensive comparative analysis of RABV gene sequence data, representing 192 isolates sampled from 55 countries. From this, we identified six clades of RABV in non-flying mammals, each of which has a distinct geographical distribution, most likely reflecting major physical barriers to gene flow. Indeed, a detailed analysis of phylogeographic structure revealed only limited viral movement among geographical localities. Using Bayesian coalescent methods we also reveal that the sampled lineages of canid RABV derive from a common ancestor that originated within the past 1500 years. Additionally, we found no evidence for either positive selection or widespread population bottlenecks during the global expansion of canid RABV. Overall, our study reveals that the stochastic processes of genetic drift and population subdivision are the most important factors shaping the global phylogeography of canid RABV.
引用
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页码:2673 / 2681
页数:9
相关论文
共 53 条
[1]  
Arai YT, 2001, ACTA VIROL, V45, P327
[2]   Host switching in Lyssavirus history from the chiroptera to the carnivora orders [J].
Badrane, H ;
Tordo, N .
JOURNAL OF VIROLOGY, 2001, 75 (17) :8096-8104
[3]   A virus reveals population structure and recent demographic history of its carnivore host [J].
Biek, R ;
Drummond, AJ ;
Poss, M .
SCIENCE, 2006, 311 (5760) :538-541
[4]   A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus [J].
Biek, Roman ;
Henderson, J. Caroline ;
Waller, Lance A. ;
Rupprecht, Charles E. ;
Real, Leslie A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (19) :7993-7998
[5]  
Bourhy H, 2005, Euro Surveill, V10, P3, DOI 10.2807/esm.10.11.00575-en
[6]   MOLECULAR DIVERSITY OF THE LYSSAVIRUS GENUS [J].
BOURHY, H ;
KISSI, B ;
TORDO, N .
VIROLOGY, 1993, 194 (01) :70-81
[7]   Ecology and evolution of rabies virus in Europe [J].
Bourhy, H ;
Kissi, B ;
Audry, L ;
Smreczak, M ;
Sadkowska-Todys, M ;
Kulonen, K ;
Tordo, N ;
Zmudzinski, JF ;
Holmes, EC .
JOURNAL OF GENERAL VIROLOGY, 1999, 80 :2545-2557
[8]   Effective sizes of macroparasite populations: a conceptual model [J].
Criscione, CD ;
Blouin, MS .
TRENDS IN PARASITOLOGY, 2005, 21 (05) :212-217
[9]   Identification of novel canine rabies virus clades in the Middle East and North Africa [J].
David, Dan ;
Hughes, Gareth J. ;
Yakobson, Boris A. ;
Davidson, Irit ;
Un, Hikmat ;
Aylan, Orhan ;
Kuzmin, Ivan V. ;
Rupprecht, Charles E. .
JOURNAL OF GENERAL VIROLOGY, 2007, 88 :967-980
[10]   The evolutionary dynamics of canid and mongoose rabies virus in southern Africa [J].
Davis, P. L. ;
Rambaut, A. ;
Bourhy, H. ;
Holmes, E. C. .
ARCHIVES OF VIROLOGY, 2007, 152 (07) :1251-1258