Isolation and absolute configuration of ent-halimane diterpenoids from Hymenaea courbaril from the suriname rain forest

被引：37

作者：

Abdel-Kader, M

Berger, JM

Slebodnick, C

Hoch, J

Malone, S

Wisse, JH

Werkhoven, MCM

Mamber, S

Kingston, DGI

机构：

[1] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA

[2] Conservat Int Suriname, Paramaribo, Suriname

[3] Natl Herbarium Suriname, Paramaribo, Suriname

[4] Commissaris Roblesweg, Bedrijf Geneesmiddelen Voorziening Suriname, Geyersvlijt, Suriname

[5] Bristol Myers Squibb Co, Pharmaceut Res Inst, Wallingford, CT 06492 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 01期

关键词：

D O I：

10.1021/np0103261

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioactivity-directed fractionation of a methanol extract of Hymenaea courbaril afforded the three new diterpenoids (13R)-13-hydroxy-1(10),14-ent-halimadien-18-oic acid (1), (2S,13R)-2,13-dihydroxy-1(10),14-ent-halimadien-18-oic acid (2), and (13R)-2-oxo-13-hydroxy-1(10),14-ent-halimadien-18-oic acid (3). The configurations of these compounds were determined from X-ray crystallography of 1, circular dichroism of 2 and 3, and spectral studies of prepared derivatives. Compound 1 exhibited weak cytotoxicity toward the 1138 mutant yeast strain and the A2780 human ovarian cancer cell line.

引用

页码：11 / 15

页数：5

共 22 条

[1] Two bioactive saponins from Albizia subdimidiata from the Suriname rainforest [J].