Two bioactive saponins from Albizia subdimidiata from the Suriname rainforest

被引：57

作者：

Abdel-Kader, M

Hoch, J

Berger, JM

Evans, R

Miller, JS

Wisse, JH

Mamber, SW

Dalton, JM

Kingston, DGI

机构：

[1] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA

[2] Missouri Bot Garden, St Louis, MO 63166 USA

[3] Bedrijf Geneesmiddelen Voorziening Suriname, Geyersvlijt, Suriname

[4] Bristol Myers Squibb Co, Pharmaceut Res Inst, Wallingford, CT 06492 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 04期

关键词：

D O I：

10.1021/np000295u

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of a methanol extract of Albizia subdimidiata using the engineered yeast strains 1138, 1140, 1353, and Sc7 of Saccharomyces cerevisiae as the bioassay tool resulted in the isolation of the two active saponins 1 and 2; one of these, albiziatrioside A (1), is described for the first time. The structures of 1 and 2 were established on the basis of HRMS, 1D and 2D NMR spectral data. and GCMS analysis of the sugar units. Both isolated compounds showed significant cytotoxicity against the A2780 cell line.

引用

页码：536 / 539

页数：4

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