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Mechanisms of ageing: Public or private?

被引：371
作者：
Partridge, L [1 ]
Gems, D [1 ]
机构：
[1] UCL, Dept Biol, London WC1E 6BT, England
来源：
NATURE REVIEWS GENETICS | 2002年 / 3卷 / 03期
基金：
英国生物技术与生命科学研究理事会;
关键词：
D O I：
10.1038/nrg753
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Ageing - the decline in survival and fecundity with advancing age - is caused by damage to macromolecules and tissues. Ageing is not a programmed process, in the sense that no genes are known to have evolved specifically to cause damage and ageing. Mechanisms of ageing might therefore not be expected to be as highly conserved between distantly related organisms as are mechanisms of development and metabolism. However, evidence is mounting that modulators of the rate of ageing are conserved over large evolutionary distances. As we discuss in this review, this conservation might stem from mechanisms that match reproductive rate to nutrient supply.
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页码：165 / 175
页数：11
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