Diastereocontrolled synthesis of hydroxylated lactams

被引：21

作者：

Andrews, MD

Brewster, AG

Moloney, MG

机构：

[1] Univ Oxford, Dyson Perrins Lab, Dept Chem, Oxford OX1 3QY, England

[2] Zeneca Pharmaceut, Macclesfield SK10 4TG, Cheshire, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2002年 / 01期

关键词：

D O I：

10.1039/b108056n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly diastereoselective reductions and organometallic additions in bicyclic lactams have been observed, which appear to result either from a stereoelectronic interaction of the pyramidalised nitrogen lone pair or from steric interactions in the bicyclic system. These products can be readily deprotected to give hydroxylated lactams.

引用

页码：80 / 90

页数：11

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