The Therapeutic Effect of Vasoactive Intestinal Peptide on Experimental Arthritis is Associated with CD4+CD25+ T Regulatory Cells

被引：26

作者：

Chen, G. ^{[1
]}

Hao, J. ^{[1
]}

Xi, Y. ^{[1
]}

Wang, W. ^{[1
]}

Wang, Z. ^{[1
]}

Li, N. ^{[1
]}

Li, W. ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Shanghai Inst Immunol, Shanghai 200025, Peoples R China

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2008年 / 68卷 / 06期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1111/j.1365-3083.2008.02178.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Vasoactive intestinal peptide (VIP) has been found to act as a potent anti-inflammatory factor through regulating the production of both anti- and pro-inflammatory mediators and promoting Th2-type responses. In this study, we used Chicken collagen II-induced experimental arthritis (CIA) model in Wistar rats to investigate the potential effects of VIP on rheumatoid arthritis. Our results showed that in vivo treatment of CIA-induced rats with VIP had great protective benefit at both clinical and histological levels. Disease suppression was associated with the inhibition of T cells proliferation, shifting of the immune response toward a Th2-type response and expanded CD4(+)CD25(+) Treg in the periphery, which inhibited autoreactive T cell activation/expansion. In conclusion, the study provides evidence that VIP had great protective effect on CIA through its inhibition actions on pathogenic T cells.

引用

页码：572 / 578

页数：7

共 29 条

[1]

Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease [J].