Fumonisin contamination of a corn sample associated with the induction of hepatocarcinogenesis in rats - role of dietary deficiencies

被引:21
作者
Gelderblom, WCA
Rheeder, JP
Leggott, N
Stockenstrom, S
Humphreys, J
Shephard, GS
Marasas, WFO
机构
[1] MRC, PROMEC Unit, ZA-7505 Tygerberg, South Africa
[2] MRC, Nutr Intervent Res Unit, ZA-7505 Tygerberg, South Africa
关键词
fumonisins; carcinogenesis; nutrition deficiencies;
D O I
10.1016/j.fct.2003.10.010
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
A corn sample associated with a field outbreak of equine leukoencephalomalacia in Pennsylvania, USA, during 1983/1984 and induced hepatotoxic and hepatocarcinogenic effects when fed to male Fischer rats was analyzed mycologically and chemically for the presence of fumonisins (FB), hydrolysed FB derivatives and aflatoxins (AFB). Fusarium verticillioides was found to be the predominant fungal contaminant in the corn sample but Aspergillus flavus was also present. Trace amounts (0.1 mug/kg) of AFB(1) and AFB(2) and a total FB level of 33.5 mg/kg (FB1:FB2:FB3 ratio of 9:2.3:1) were found. No hydrolysed FB derivatives or AFG(1) and AFG(2) were detected. Based on the chemical stability of the fumonisins in different corn cultures of F. verticillioides kept at 4 degreesC over a period of 13-20 years, a level of approximately 55 mg/kg of total FB is estimated in the original corn sample. A possible role of certain dietary constituents such as the high protein content and deficiencies in certain micronutrients is evaluated to address differences in the organ-specific toxicity of FBI in rats using commercial, semi-purified, purified and corn-only diets. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:471 / 479
页数:9
相关论文
共 34 条
[11]   The cancer-promoting potential of fumonisin B-1 in rat liver using diethylnitrosamine as a cancer initiator [J].
Gelderblom, WCA ;
Snyman, SD ;
LebepeMazur, S ;
vanderWesthuizen, L ;
Kriek, NPJ ;
Marasas, WFO .
CANCER LETTERS, 1996, 109 (1-2) :101-108
[12]  
Howard PC, 2001, ENVIRON HEALTH PERSP, V109, P277, DOI 10.2307/3435019
[13]  
JASKIEWICZ K, 1987, JNCI-J NATL CANCER I, V78, P321
[14]   HEPATITIS IN VERVET MONKEYS CAUSED BY FUSARIUM-MONILIFORME [J].
JASKIEWICZ, K ;
MARASAS, WFO ;
TALJAARD, JJF .
JOURNAL OF COMPARATIVE PATHOLOGY, 1987, 97 (03) :281-291
[15]  
*JECFA, 2001, FOOD ADD SER, V47
[16]  
KRIEK NPJ, 1981, ONDERSTEPOORT J VET, V48, P129
[17]  
Langenhoven M., 1991, MRC FOOD COMPOSITION, V3rd
[18]   PRIMARY LIVER-CANCER AND ESOPHAGEAL BASAL-CELL HYPERPLASIA IN RATS CAUSED BY FUSARIUM-MONILIFORME [J].
MARASAS, WFO ;
KRIEK, NPJ ;
FINCHAM, JE ;
VANRENSBURG, SJ .
INTERNATIONAL JOURNAL OF CANCER, 1984, 34 (03) :383-387
[19]   A METHOD OF DETECTION OF FUMONISINS IN CORN SAMPLES ASSOCIATED WITH FIELD CASES OF EQUINE LEUKOENCEPHALOMALACIA [J].
PLATTNER, RD ;
NORRED, WP ;
BACON, CW ;
VOSS, KA ;
PETERSON, R ;
SHACKELFORD, DD ;
WEISLEDER, D .
MYCOLOGIA, 1990, 82 (06) :698-702
[20]   BIOLOGICAL TESTING OF FOOD GROWN IN TRANSKEI [J].
PURCHASE, IFH ;
TUSTIN, RC ;
VANRENSBURG, SJ .
FOOD AND COSMETICS TOXICOLOGY, 1975, 13 (06) :639-&