Microbiological and immunological strategies for treatment of inflammatory bowel disease

被引：23

作者：

Steidler, L

机构：

[1] Flanders Interuniv Inst Biotechnol, Dept Mol Biol, B-9000 Ghent, Belgium

[2] State Univ Ghent, B-9000 Ghent, Belgium

来源：

MICROBES AND INFECTION | 2001年 / 3卷 / 13期

关键词：

inflammatory bowel disease; immunological therapeutics; delivery; probiotics;

D O I：

10.1016/S1286-4579(01)01476-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic inflammatory bowel diseases such as Crohn's disease or ulcerative colitis, affect around 1 in every 1 000 individuals in western countries. They probably result from an inappropriate reaction towards the commensal microflora and are currently treated with antiinflammatory drugs or surgery. Novel strategies aim at blocking lymphocyte recruitment and activation, improved targeting of therapeutics and modification of gut microflora. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

收藏

页码：1157 / 1166

页数：10

相关论文

共 98 条

[11] SHORT CHAIN FATTY-ACIDS IN THE HUMAN-COLON [J].

CUMMINGS, JH .

GUT, 1981, 22 (09) :763-779

[12]

D'Argenio G, 1999, ADV EXP MED BIOL, V472, P149

[13] T cell specificity and cross reactivity towards enterobacteria, Bacteroides, Bifidobacterium, and antigens from resident intestinal flora in humans [J].

Duchmann, R ;

May, E ;

Heike, M ;

Knolle, P ;

Neurath, M ;

zum Büschenfelde, KHM .

GUT, 1999, 44 (06) :812-818

[14] Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12 [J].

Duchmann, R ;

Schmitt, E ;

Knolle, P ;

zumBuschenfelde, KHM ;

Neurath, M .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (04) :934-938

[15] Interactions mediating bacterial translocation in the immature intestine [J].

Duffy, LC .

JOURNAL OF NUTRITION, 2000, 130 (02) :432S-436S

[16] Probiotics: from myth to reality. Demonstration of functionality in animal models of disease and in human clinical trials [J].

Dunne, C ;

Murphy, L ;

Flynn, S ;

O'Mahony, L ;

O'Halloran, S ;

Feeney, M ;

Morrissey, D ;

Thornton, G ;

Fitzgerald, G ;

Daly, C ;

Kiely, B ;

Quigley, EMM ;

O'Sullivan, GC ;

Shanahan, F ;

Collins, JK .

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 1999, 76 (1-4) :279-292

[17]

Ehrhardt RO, 1997, J IMMUNOL, V158, P566

[18] IMPAIRMENT OF BACTERIAL-FLORA IN HUMAN ULCERATIVE-COLITIS AND EXPERIMENTAL COLITIS IN THE RAT [J].

FABIA, R ;

ARRAJAB, A ;

JOHANSSON, ML ;

ANDERSSON, R ;

WILLEN, R ;

JEPPSSON, B ;

MOLIN, G ;

BENGMARK, S .

DIGESTION, 1993, 54 (04) :248-255

[19] Fecal beta-D-galactosidase production and Bifidobacteria are decreased in Crohn's disease [J].

Favier, C ;

Neut, C ;

Mizon, C ;

Cortot, A ;

Colombel, JF ;

Mizon, J .

DIGESTIVE DISEASES AND SCIENCES, 1997, 42 (04) :817-822

[20] Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children [J].

Fukushima, Y ;

Kawata, Y ;

Hara, H ;

Terada, A ;

Mitsuoka, T .

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 1998, 42 (1-2) :39-44

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