Strategies for reconstituting and boosting T cell-based immunity following haematopoietic stem cell transplantation: pre-clinical and clinical approaches

被引:22
作者
Chidgey, Ann P. [1 ]
Seach, Natalie [1 ]
Dudakov, Jarrod [1 ]
Hammett, Maree V. [1 ]
Boyd, Richard L. [1 ]
机构
[1] Monash Univ, STRIP, Monash Immunol & Stem Cell Labs, Clayton, Vic 3800, Australia
基金
英国医学研究理事会;
关键词
Thymus; Ageing; Regeneration; Stem cells; Immune reconstitution;
D O I
10.1007/s00281-008-0140-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Poor immune recovery is characteristic of bone marrow transplantation and leads to high levels of morbidity and mortality. The primary underlying cause is a compromised thymic function, resulting from age-induced atrophy and further compounded by the damaging effects of cytoablative conditioning regimes on thymic epithelial cells (TEC). Several strategies have been proposed to enhance T cell reconstitution. Some, such as the use of single biological agents, are currently being tested in clinical trials. However, a more rational approach to immune restoration will be to leverage the evolving repertoire of new technologies. Specifically, the combined targeting of TEC, thymocytes and peripheral T cells, together with the bone marrow niches, promises a more strategic clinical therapeutic platform.
引用
收藏
页码:457 / 477
页数:21
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