MicroRNAs: key regulators of stem cells

被引：559

作者：

Gangaraju, Vamsi K. ^{[1
]}

Lin, Haifan ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Yale Stem Cell Ctr, New Haven, CT 06520 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 02期

基金：

美国国家卫生研究院;

关键词：

MIRNA EXPRESSION; DNA METHYLATION; SELF-RENEWAL; MOUSE; DIFFERENTIATION; DICER; RNA; PATHWAY; PIWI; ERYTHROPOIESIS;

D O I：

10.1038/nrm2621

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The hallmark of a stem cell is its ability to self-renew and to produce numerous differentiated cells. This unique property is controlled by dynamic interplays between extrinsic signalling, epigenetic, transcriptional and post-transcriptional regulations. Recent research indicates that microRNAs (miRNAs) have an important role in regulating stem cell self-renewal and differentiation by repressing the translation of selected mRNAs in stem cells and differentiating daughter cells. Such a role has been shown in embryonic stem cells, germline stem cells and various somatic tissue stem cells. These findings reveal a new dimension of gene regulation in controlling stem cell fate and behaviour.

引用

页码：116 / 125

页数：10

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