Post-Stroke Immunodeficiency: Effects of Sensitization and Tolerization to Brain Antigens

被引：26

作者：

Esmaeili, Arash ^{[1
,2
]}

Dadkhahfar, Sahar ^{[1
,2
]}

Fadakar, Kaveh ^{[1
,2
]}

Rezaei, Nima ^{[2
,3
,4
]}

机构：

[1] Univ Tehran Med Sci, Brain & Spinal Injuries Repair Res Ctr, Dept Immunol, Sch Med, Tehran, Iran

[2] Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Childrens Med Ctr, Dept Immunol,Sch Med, Tehran, Iran

[3] Univ Tehran Med Sci, Mol Immunol Res Ctr, Dept Immunol, Sch Med, Tehran, Iran

[4] Univ Sheffield, Sch Med & Biomed Sci, Dept Infect & Immun, Sheffield, S Yorkshire, England

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2012年 / 31卷 / 05期

关键词：

immunodeficiency; stroke; systemic inflammatory response syndrome; tolerization; ACUTE ISCHEMIC-STROKE; PREVENTIVE ANTIBACTERIAL THERAPY; URINARY-TRACT-INFECTION; TOLL-LIKE RECEPTORS; CD4(+) T-CELLS; INFLAMMATORY RESPONSE; MUCOSAL TOLERANCE; DENDRITIC CELLS; IN-VITRO; INDUCED IMMUNODEPRESSION;

D O I：

10.3109/08830185.2012.723078

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Acute onset of cerebrovascular diseases seems to be related to a number of immunological alternations. After the initial pro-inflammatory response to brain ischemia accompanied by systemic inflammatory response syndrome, stroke interferes with function of the innate and the adaptive immunecells, resulting in systemic immunosuppression. Although post-stroke immunodeficiency could predispose patients to life-threatening infections, it could potentially protect brain via reducing autoimmune reaction to the brain antigens. In this paper, we review current knowledge on the immunological alterations after brain ischemia, particularly effects of infection for stimulation of autoimmune response against brain antigens.

引用

页码：396 / 409

页数：14

共 112 条

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Neuroprotection from Stroke in the Absence of MHCI or PirB [J].