Immunoglobulin A A next generation of therapeutic antibodies?

被引：74

作者：

Bakema, Jantine E. ^{[1
]}

van Egmond, Marjolein ^{[1
,2
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Dept Surg, Amsterdam, Netherlands

来源：

MABS | 2011年 / 3卷 / 04期

关键词：

IgA; SIgA; dIgA; CD89; FcaRI; therapy; pro-inflammatory; mucosal defence; tumor; ITAM;

D O I：

10.4161/mabs.3.4.16092

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Although immunoglobulin (Ig) A is commonly recognized as the most prevalent antibody subclass at mucosal sites with an important role in mucosal defense, its potential as a therapeutic monoclonal antibody is less well known. However, IgA has multifaceted anti-, non- and pro-inflammatory functions that can be exploited for different immunotherapeutical strategies, which will be the focus of this review.

引用

页码：352 / 361

页数：10

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