The process analytical technology initiative and multivariate process analysis, monitoring and control

被引：79

作者：

Kourti, T ^{[1
]}

机构：

[1] McMaster Univ, Dept Chem Engn, Hamilton, ON L8S 4L7, Canada

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2006年 / 384卷 / 05期

关键词：

process analytical technology; abnormal situation detection; process analysis; process understanding; multivariate analysis; multivariate statistical process control;

D O I：

10.1007/s00216-006-0303-y

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Process analytical technology is an essential step forward in pharmaceutical industry. Real-time analyzers will provide timely data on quality properties. This information combined with process data (temperatures, flow rates, pressure readings) collected in real time can become a powerful tool for this industry, for process understanding, process and quality monitoring, abnormal situation detection and for improving product quality and process reliability. A very important tool for this achievement is the multivariate analysis.

引用

页码：1043 / 1048

页数：6

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