Paternal age effect of YY aneuploidy in human sperm, as assessed by fluorescence in situ hybridization

被引：64

作者：

Kinakin, B

Rademaker, A

Martin, R

机构：

[1] ALBERTA CHILDRENS PROV GEN HOSP,DEPT GENET,CALGARY,AB T2T 5C7,CANADA

[2] UNIV CALGARY,DEPT MED GENET,CALGARY,AB,CANADA

[3] NORTHWESTERN UNIV,SCH MED,CTR CANC,BIOMETRY SECT,CHICAGO,IL 60611

来源：

CYTOGENETICS AND CELL GENETICS | 1997年 / 78卷 / 02期

关键词：

D O I：

10.1159/000134641

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sperm samples were collected from 18 healthy men of various ages. Multicolor FISH was performed on each sample, using probes for the sex chromosomes and chromosome 1. A minimum of 10,000 sperm per donor was analyzed. The Pearson correlation coefficient was used to determine if there was an association between donor age and disomy frequency for the sex chromosomes.

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页码：116 / 119

页数：4

相关论文

共 12 条

[1]

BOND DJ, 1983, ANEUPLOIDY, V11, P62

[2] CLONING OF HUMAN SATELLITE-III DNA - DIFFERENT COMPONENTS ARE ON DIFFERENT CHROMOSOMES [J].

COOKE, HJ ;

HINDLEY, J .

NUCLEIC ACIDS RESEARCH, 1979, 6 (10) :3177-3197

[3] NONDISJUNCTION IN HUMAN SPERM - EVIDENCE FOR AN EFFECT OF INCREASING PATERNAL AGE [J].

GRIFFIN, DK ;

ABRUZZO, MA ;

MILLIE, EA ;

SHEEAN, LA ;

FEINGOLD, E ;

SHERMAN, SL ;

HASSOLD, TJ .

HUMAN MOLECULAR GENETICS, 1995, 4 (12) :2227-2232

[4] CHROMOSOME-ABNORMALITIES IN HUMAN REPRODUCTIVE WASTAGE [J].

HASSOLD, TJ .

TRENDS IN GENETICS, 1986, 2 (04) :105-110

[5] MACROMOLECULAR ORGANIZATION OF HUMAN CENTROMERIC REGIONS REVEALS HIGH-FREQUENCY, POLYMORPHIC MACRO DNA REPEATS [J].

JABS, EW ;

GOBLE, CA ;

CUTTING, GR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (01) :202-206

[6]

MARTIN RH, 1987, AM J HUM GENET, V41, P484

[7] RELIABILITY OF ANEUPLOIDY ESTIMATES IN HUMAN SPERM - RESULTS OF FLUORESCENCE IN-SITU HYBRIDIZATION STUDIES USING 2 DIFFERENT SCORING CRITERIA [J].

MARTIN, RH ;

RADEMAKER, A .

MOLECULAR REPRODUCTION AND DEVELOPMENT, 1995, 42 (01) :89-93

[8] EFFECT OF CRYOPRESERVATION ON THE FREQUENCY OF CHROMOSOMAL-ABNORMALITIES AND SEX-RATIO IN HUMAN SPERM [J].

MARTIN, RH ;

CHERNOS, JE ;

RADEMAKER, AW .

MOLECULAR REPRODUCTION AND DEVELOPMENT, 1991, 30 (02) :159-163

[9]

MARTIN RH, 1995, AM J HUM GENET, V57, P1395

[10] Three-probe fluorescence in situ hybridization to assess chromosome X, Y, and 8 aneuploidy in sperm of 14 men from two healthy groups: Evidence for a paternal age effect on sperm aneuploidy [J].

Robbins, WA ;

Baulch, JE ;

Moore, D ;

Weier, HU ;

Blakey, D ;

Wyrobek, AJ .

REPRODUCTION FERTILITY AND DEVELOPMENT, 1995, 7 (04) :799-809