The functional domains in p53 family proteins exhibit both common and distinct properties

被引:77
作者
Harms, K. L. [1 ]
Chen, X. [1 ]
机构
[1] Univ Alabama Birmingham, Dept Cell Biol, Birmingham, AL 35294 USA
关键词
D O I
10.1038/sj.cdd.4401904
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:890 / 897
页数:8
相关论文
共 53 条
[11]   Structural details on mdm2-p53 interaction [J].
Chi, SW ;
Lee, SH ;
Kim, DH ;
Ahn, MJ ;
Kim, JS ;
Woo, JY ;
Torizawa, T ;
Kainosho, M ;
Han, KH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (46) :38795-38802
[12]   CRYSTAL-STRUCTURE OF A P53 TUMOR-SUPPRESSOR DNA COMPLEX - UNDERSTANDING TUMORIGENIC MUTATIONS [J].
CHO, YJ ;
GORINA, S ;
JEFFREY, PD ;
PAVLETICH, NP .
SCIENCE, 1994, 265 (5170) :346-355
[13]   Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome [J].
Davison, TS ;
Yin, P ;
Nie, E ;
Kay, C ;
Arrowsmith, CH .
ONCOGENE, 1998, 17 (05) :651-656
[14]   The N-terminal domain of p53 is natively unfolded [J].
Dawson, R ;
Müller, L ;
Dehner, A ;
Klein, C ;
Kessler, H ;
Buchner, J .
JOURNAL OF MOLECULAR BIOLOGY, 2003, 332 (05) :1131-1141
[15]   p63α and ΔNp63α can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes [J].
Dohn, M ;
Zhang, SZ ;
Chen, XB .
ONCOGENE, 2001, 20 (25) :3193-3205
[16]   Thermal unfolding simulations of a multimeric protein - Transition state and unfolding pathways [J].
Duan, JX ;
Nilsson, L .
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2005, 59 (02) :170-182
[17]   Intrinsically unstructured proteins and their functions [J].
Dyson, HJ ;
Wright, PE .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (03) :197-208
[18]   The proline-rich region of mouse p53 influences transactivation and apoptosis but is largely dispensable for these functions [J].
Edwards, SJ ;
Hananeia, L ;
Eccles, MR ;
Zhang, YF ;
Braithwaite, AW .
ONCOGENE, 2003, 22 (29) :4517-4523
[19]   Tumor predisposition in mice mutant for p63 and p73:: Evidence for broader tumor suppressor functions for the p53 family [J].
Flores, ER ;
Sengupta, S ;
Miller, JB ;
Newman, JJ ;
Bronson, R ;
Crowley, D ;
Yang, A ;
McKeon, F ;
Jacks, T .
CANCER CELL, 2005, 7 (04) :363-373
[20]   The common and distinct target genes of the p53 family transcription factors [J].
Harms, K ;
Nozell, S ;
Chen, X .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2004, 61 (7-8) :822-842