Multiresidue analysis of quinolones and fluoroquinolones in soil by ultrasonic-assisted extraction in small columns and HPLC-UV

被引：145

作者：

Turiel, E ^{[1
]}

Martín-Esteban, A ^{[1
]}

Tadeo, JL ^{[1
]}

机构：

[1] INIA, Dep Med Ambiente, Madrid 28040, Spain

来源：

ANALYTICA CHIMICA ACTA | 2006年 / 562卷 / 01期

关键词：

ultrasonic-assisted extraction; soil; HPLC-UV; quinolones and fluoroquinolones;

D O I：

10.1016/j.aca.2006.01.054

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this work, a new and simple analytical methodology for the simultaneous analysis of several quinolones (cinoxacin, oxolinic acid, nalidixic acid and flumequine) and fluoroquinolones (norfloxacin, enrofloxacin, enoxacin, ciprofloxacin and danofloxacin) in soil samples is presented. The method is based on the extraction of these analytes by an ultrasonic-assisted extraction in small columns and their subsequent quantification by HPLC using UV detection. The observed strong sorption of quinolones and fluoroquinlones to soil together their different acid-base properties made necessary an exhaustive optimisation of the extraction step. The optimum extraction procedure, based on the formation of antibiotic-Mg(II) complexes, allowed to desorb and quantitatively extract both groups of antibiotics in a single step, which was not possible by using conventional organic solvents. The proposed method was validated and the limits of detection achieved were in the low mu g g(-1) concentration range proving its suitability for the determination of quinolones and fluoroquinolones in soil samples at realistic environmental concentration level. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：30 / 35

页数：6

共 17 条

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