Apolipoprotein E-ε4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV

被引：14

作者：

Jayasuriya, A. N. ^{[3
]}

Itzhaki, R. F. ^{[1
]}

Wozniak, M. A. ^{[1
]}

Patel, R. ^{[2
]}

Smit, E. J. ^{[3
]}

Noone, R. ^{[1
]}

Gilleran, G. ^{[3
]}

Taylor, S. ^{[3
]}

White, D. J. ^{[3
]}

机构：

[1] Univ Manchester, Manchester, Lancs, England

[2] Univ Southampton, Southampton, Hants, England

[3] Birmingham Heartlands Hosp, Birmingham, W Midlands, England

来源：

SEXUALLY TRANSMITTED INFECTIONS | 2008年 / 84卷 / 07期

关键词：

D O I：

10.1136/sti.2008.032367

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Apolipoprotein E ( APOE) alleles have been associated with the severity of, or susceptibility to, infection by various microbes. We investigated the potential association between the APOE-e4 allele and the rate of recurrence of genital herpes in patients who were HIV positive and herpes simplex virus type 2 (HSV-2) seropositive. The APOE-e4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count ( OR 8.3; 95% CI 2.4 to 28.5). To our knowledge, this is the first published study to demonstrate this association and suggests that APOE-e4 may represent a future prognostic marker for symptomatic recurrence of genital herpes in individuals with HIV.

引用

页码：516 / 517

页数：2

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