Stable Introduction of a Life-Shortening Wolbachia Infection into the Mosquito Aedes aegypti

被引：689

作者：

McMeniman, Conor J. ^{[1
]}

Lane, Roxanna V. ^{[1
]}

Cass, Bodil N. ^{[1
]}

Fong, Amy W. C. ^{[1
]}

Sidhu, Manpreet ^{[1
]}

Wang, Yu-Feng ^{[1
,2
]}

O'Neill, Scott L. ^{[1
]}

机构：

[1] Univ Queensland, Sch Integrat Biol, Brisbane, Qld 4072, Australia

[2] Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China

来源：

SCIENCE | 2009年 / 323卷 / 5910期

关键词：

CYTOPLASMIC INCOMPATIBILITY; VIRULENT WOLBACHIA; TRANSMISSION; DROSOPHILA; AGE; TEMPERATURE; STRAIN;

D O I：

10.1126/science.1165326

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Most pathogens require a relatively long period of development in their mosquito vector before they can be transmitted to a new human host; hence, only older insects are of epidemiological importance. The successful transfer of a life- shortening strain of the inherited bacterial symbiont, Wolbachia, into the major mosquito vector of dengue, Aedes aegypti, halved adult life span under laboratory conditions. The association is stable, and the Wolbachia strain is maternally inherited at high frequency. It is capable of inducing complete cytoplasmic incompatibility, which should facilitate its invasion into natural field populations and its persistence over time. Our data suggest that targeting mosquito age with inherited Wolbachia infections may be a viable strategy to reduce the transmission of pathogens such as dengue viruses.

引用

页码：141 / 144

页数：4

共 25 条

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