Anti-craving compounds for ethanol: New pharmacological tools to study addictive processes

被引:208
作者
Spanagel, R [1 ]
Zieglgansberger, W [1 ]
机构
[1] MAX PLANCK INST PSYCHIAT, CLIN NEUROPHARMACOL GRP, INST CLIN, D-80804 MUNICH, GERMANY
关键词
D O I
10.1016/S0165-6147(97)89800-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Anti-craving compounds have recently been registered for relapse prophylaxis in weaned alcoholics in various European countries (acamprosate), and in the United States (naltrexone). Acamprosate, the Ca2+-salt of N-acetyl-homotaurinate, interacts with NMDB receptor-mediated glutamatergic neurotransmission in various brain regions and reduces Ca2+ fluxes through voltage-operated channels. The opioid receptor antagonist naltrexone most likely interferes with alcohol-induced reinforcement via the block of opioid receptors. In this article Rainer Spanagel and Walter Zieglgansberger discuss the pivotal role of incremental neuroadaptation to alcohol and alcohol-associated stimuli for craving, and the possible mechanisms of action underlying the anti-craving properties of acamprosate and naltrexone.
引用
收藏
页码:54 / 59
页数:6
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