The Role of Parental and Grandparental Epigenetic Alterations in Familial Cancer Risk

被引：23

作者：

Fleming, Jessica L. ^{[1
,2
]}

Huang, Tim H-M. ^{[1
,2
]}

Toland, Amanda Ewart ^{[1
,2
,3
]}

机构：

[1] Ohio State Univ, Human Canc Genet Program, Columbus, OH 43210 USA

[2] Ohio State Univ, Ohio State Comprehens Canc Ctr, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Internal Med, Columbus, OH 43210 USA

来源：

CANCER RESEARCH | 2008年 / 68卷 / 22期

关键词：

D O I：

10.1158/0008-5472.CAN-08-2184

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epigenetic alterations of the genome such as DNA promoter methylation and chromatin remodeling play an important role in tumorigenesis. These modifications take place throughout development with subsequent events occurring later in adulthood. Recent studies, however, suggest that some epigenetic alterations that influence cancer risk are inherited through the germline from parent to child and are observed in multiple generations. Epigenetic changes may be inherited as Mendelian, non-Mendelian, or environmentally induced traits. Here, we will discuss Mendelian, non-Mendelian, and environmentally induced patterns of multigenerational epigenetic alterations as well as some possible mechanisms for how these events may be occurring. [Cancer Res 2008;68(22):9116-21]

引用

页码：9116 / 9121

页数：6

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