Distinct synaptic loci of Ca2+/calmodulin-dependent protein kinase II necessary for long-term potentiation and depression

被引:49
作者
Stanton, PK [1 ]
Gage, AT [1 ]
机构
[1] ALBERT EINSTEIN COLL MED,DEPT NEUROL,BRONX,NY 10461
关键词
D O I
10.1152/jn.1996.76.3.2097
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1. Extracellular bath application of the selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor KN-62 to hippocampal slices in vitro blocked the induction of long-term depression(LTD) by low-frequency Schaffer collateral stimulation (1 Hz/15 min) at the same concentration as has been shown previously to prevent induction of long-term potentiation (LTP) at these synapses. 2. In contrast, postsynaptic intracellular infusion of KN-62 into single CA1 pyramidal neurons did not prevent induction of LTD, although it was quite effective in blocking LTP. 3. We conclude that there is a presynaptic CaMKII that must be activated to induce LTD, whereas postsynaptic CaMKII stimulation is needed to evoke LTP. 4. Bath application of KN-62 also blocked depotentiation by low-frequency stimuli of previously induced LTP, suggesting that induction of depotentiation and de novo LTD may require the same CaMKII-dependent mechanisms.
引用
收藏
页码:2097 / 2101
页数:5
相关论文
共 20 条
[1]   DIFFERENT VOLTAGE-DEPENDENT THRESHOLDS FOR INDUCING LONG-TERM DEPRESSION AND LONG-TERM POTENTIATION IN SLICES OF RAT VISUAL-CORTEX [J].
ARTOLA, A ;
BROCHER, S ;
SINGER, W .
NATURE, 1990, 347 (6288) :69-72
[2]   POSTSYNAPTIC INDUCTION AND PRESYNAPTIC EXPRESSION OF HIPPOCAMPAL LONG-TERM DEPRESSION [J].
BOLSHAKOV, VY ;
SIEGELBAUM, SA .
SCIENCE, 1994, 264 (5162) :1148-1152
[3]   HOMOSYNAPTIC LONG-TERM DEPRESSION IN AREA CA1 OF HIPPOCAMPUS AND EFFECTS OF N-METHYL-D-ASPARTATE RECEPTOR BLOCKADE [J].
DUDEK, SM ;
BEAR, MF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4363-4367
[4]  
FUGUNAGA K, 1995, J BIOL CHEM, V270, P6119
[5]   LONG-TERM DEPRESSION IS INDUCED IN CA-2+/ CALMODULIN KINASE-INHIBITED VISUAL-CORTEX NEURONS [J].
FUNAUCHI, M ;
TSUMOTO, T ;
NISHIGORI, A ;
YOSHIMURA, Y ;
HIDAKA, H .
NEUROREPORT, 1992, 3 (02) :173-176
[6]   EFFECTS OF KN-62, A SPECIFIC INHIBITOR OF CALCIUM CALMODULIN-DEPENDENT PROTEIN KINASE-II, ON LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPUS [J].
ITO, I ;
HIDAKA, H ;
SUGIYAMA, H .
NEUROSCIENCE LETTERS, 1991, 121 (1-2) :119-121
[7]   CYCLIC ADP RIBOSE ACTIVATION OF THE RYANODINE RECEPTOR IS MEDIATED BY CALMODULIN [J].
LEE, HC ;
AARHUS, R ;
GRAEFF, R ;
GURNACK, ME ;
WALSETH, TF .
NATURE, 1994, 370 (6487) :307-309
[8]   AN ESSENTIAL ROLE FOR POSTSYNAPTIC CALMODULIN AND PROTEIN-KINASE ACTIVITY IN LONG-TERM POTENTIATION [J].
MALENKA, RC ;
KAUER, JA ;
PERKEL, DJ ;
MAUK, MD ;
KELLY, PT ;
NICOLL, RA ;
WAXHAM, MN .
NATURE, 1989, 340 (6234) :554-557
[9]   INHIBITION OF POSTSYNAPTIC PKC OR CAMKII BLOCKS INDUCTION BUT NOT EXPRESSION OF LTP [J].
MALINOW, R ;
SCHULMAN, H ;
TSIEN, RW .
SCIENCE, 1989, 245 (4920) :862-866
[10]   CAMKII REGULATES THE FREQUENCY-RESPONSE FUNCTION OF HIPPOCAMPAL SYNAPSES FOR THE PRODUCTION OF BOTH LTD AND LTP [J].
MAYFORD, M ;
WANG, J ;
KANDEL, ER ;
ODELL, TJ .
CELL, 1995, 81 (06) :891-904