Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice

被引：60

作者：

Mohun, Timothy ^{[1
]}

Adams, David J. ^{[2
]}

Baldock, Richard ^{[3
]}

Bhattacharya, Shoumo ^{[4
]}

Copp, Andrew J. ^{[5
]}

Hemberger, Myriam ^{[6
]}

Houart, Corinne ^{[7
]}

Hurles, Matt E. ^{[2
]}

Robertson, Elizabeth ^{[4
]}

Smith, James C. ^{[1
]}

Weaver, Tom ^{[8
]}

Weninger, Wolfgang ^{[9
]}

机构：

[1] Natl Inst Med Res, MRC, London NW7 1AA, England

[2] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[3] Univ Edinburgh, Edinburgh EH4 2XU, Midlothian, Scotland

[4] Univ Oxford, Oxford OX3 7BN, England

[5] UCL Inst Child Hlth, London WC1E 6BT, England

[6] Babraham Inst, Cambridge CB22 3AT, England

[7] Kings Coll London, London SE1 1UL, England

[8] MRC Harwell, Oxford OX11 0RD, England

[9] Med Univ Vienna, A-1010 Vienna, Austria

来源：

DISEASE MODELS & MECHANISMS | 2013年 / 6卷 / 03期

关键词：

GENE-EXPRESSION ANALYSIS; MOUSE;

D O I：

10.1242/dmm.011957

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

International efforts to test gene function in the mouse by the systematic knockout of each gene are creating many lines in which embryonic development is compromised. These homozygous lethal mutants represent a potential treasure trove for the biomedical community. Developmental biologists could exploit them in their studies of tissue differentiation and organogenesis; for clinical researchers they offer a powerful resource for investigating the origins of developmental diseases that affect newborns. Here, we outline a new programme of research in the UK aiming to kickstart research with embryonic lethal mouse lines. The 'Deciphering the Mechanisms of Developmental Disorders' (DMDD) programme has the ambitious goal of identifying all embryonic lethal knockout lines made in the UK over the next 5 years, and will use a combination of comprehensive imaging and transcriptomics to identify abnormalities in embryo structure and development. All data will be made freely available, enabling individual researchers to identify lines relevant to their research. The DMDD programme will coordinate its work with similar international efforts through the umbrella of the International Mouse Phenotyping Consortium [see accompanying Special Article (Adams et al., 2013)] and, together, these programmes will provide a novel database for embryonic development, linking gene identity with molecular profiles and morphology phenotypes. © 2013. Published by The Company of Biologists Ltd.

引用

页码：562 / 566

页数：5

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