Visualizing Vertebrate Embryos with Episcopic 3D Imaging Techniques

被引：36

作者：

Geyer, Stefan H. ^{[1
]}

Mohun, Timothy J. ^{[2
]}

Weninger, Wolfgang J. ^{[1
]}

机构：

[1] Med Univ Vienna, Ctr Anat & Cell Biol, Vienna, Austria

[2] MRC Natl Inst Med Res, Dev Biol Div, London, England

来源：

THESCIENTIFICWORLDJOURNAL | 2009年 / 9卷

基金：

英国医学研究理事会;

关键词：

3D modeling; imaging; embryo; episcopic microscopy; development; MAGNETIC-RESONANCE MICROSCOPY; OPTICAL COHERENCE TOMOGRAPHY; TRANSGENIC MOUSE EMBRYOS; GENE-EXPRESSION PATTERNS; HIGH-RESOLUTION MRI; 3-DIMENSIONAL RECONSTRUCTION; SERIAL SECTIONS; DEVELOPMENTAL BIOLOGY; CARDIAC DEVELOPMENT; PROJECTION TOMOGRAPHY;

D O I：

10.1100/tsw.2009.154

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The creation of highly detailed, three-dimensional (3D) computer models is essential in order to understand the evolution and development of vertebrate embryos, and the pathogenesis of hereditary diseases. A still-increasing number of methods allow for generating digital volume data sets as the basis of virtual 3D computer models. This work aims to provide a brief overview about modern volume data-generation techniques, focusing on episcopic 3D imaging methods. The technical principles, advantages, and problems of episcopic 3D imaging are described. The strengths and weaknesses in its ability to visualize embryo anatomy and labeled gene product patterns, specifically, are discussed.

引用

页码：1423 / 1437

页数：15

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