Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1

被引：74

作者：

Lechleider, RJ ^{[1
]}

deCaestecker, MP ^{[1
]}

Dehejia, A ^{[1
]}

Polymeropoulos, MH ^{[1
]}

Roberts, AB ^{[1
]}

机构：

[1] NATL CTR HUMAN GENOME RES,LAB GENET DIS RES,GENE MAPPING UNIT,BETHESDA,MD 20892

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1996年 / 271卷 / 30期

关键词：

D O I：

10.1074/jbc.271.30.17617

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transforming growth factor-beta (TGF-beta) superfamily regulates a multitude of cellular and developmental events. TGF-beta family ligands signal through transmembrane serine/threonine kinase receptors whose downstream effecters are largely unknown, Using genetic data from the fruit fly, we have identified a downstream effector of TGF-beta-induced signaling. TGF-beta signaling protein-1 (BSP-1) is rapidly phosphorylated in response to TGF-beta. Localization of bsp-l to chromosome 4q28 suggests a role in carcinogenesis. These data suggest that BSP-1 is the prototype of a new class of signaling molecules.

引用

页码：17617 / 17620

页数：4

共 36 条

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