Antitumor and immunomodulatory activities of a polysaccharide from Artemisia argyi

被引：136

作者：

Bao, Xiaoli ^{[1
,2
]}

Yuan, Huihui ^{[3
]}

Wang, Chengzhong ^{[1
,2
]}

Liu, Jinjin ^{[1
,2
]}

Lan, Minbo ^{[1
,2
,4
]}

机构：

[1] E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

[2] E China Univ Sci & Technol, Res Ctr Anal & Test, Shanghai 200237, Peoples R China

[3] E China Univ Sci & Technol, Inst Appl Chem, Shanghai 200237, Peoples R China

[4] E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2013年 / 98卷 / 01期

关键词：

Artemisia argyi; Polysaccharide; Antitumor; Immunomodulation; CANCER; CELLS; INFLAMMATION; PURIFICATION; FLAVONOIDS; SEPARATION; JACEOSIDIN; BLOOD; ROOT; L;

D O I：

10.1016/j.carbpol.2013.07.018

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A water-soluble polysaccharide (FAAP-02), composed of N-acetyl-D-glucosamine, glucose, mannose, galactose, rhamnose, arabinose, xylose and ribose, with an average molecular weight of 5169 Da, was isolated from Artemisia argyi. The antitumor and immunomodulatory activities of FAAP-02 were evaluated in Sarcoma 180 (S180) tumor-bearing mice by intraperitoneal administration. As a result, FAAP-02 significantly inhibited the growth of the S180 transplanted tumors and prolonged the survival time of the tumor-bearing mice. Moreover, FAAP-02 could obviously increase the thymus and spleen indices, the levels of serum Interleukin 2 (IL-2), Interleukin 6 (IL-6), Interleukin 12 (IL-12) and tumor necrosis factor-alpha (TNF-alpha) and the expression of CD4+ and CD8+ splenic T lymphocytes which were suppressed by the transplanted tumor or/and 5-fluorouracil (5-FU) in the mice. These results indicated that the antitumor activity of FAAP-02 might be associated with its immunostimulatory effects. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1236 / 1243

页数：8

共 50 条

[1]

Adams J. D., 2012, Chinese Medicine, V3, P116

[2] Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi [J].

Adams, Michael ;

Efferth, Thomas ;

Bauer, Rudolf .

PLANTA MEDICA, 2006, 72 (09) :862-864

[3] Inflammation and cancer: How hot is the link? [J].

Aggarwal, Bharat B. ;

Shishodia, Shishir ;

Sandur, Santosh K. ;

Pandey, Manoj K. ;

Sethi, Gautam .

BIOCHEMICAL PHARMACOLOGY, 2006, 72 (11) :1605-1621

[4] Antitumor and immunomodulating activity of a polysaccharide from Sophora flavescens Ait. [J].

Bai, Lu ;

Zhu, Li-Ying ;

Yang, Bao-Shan ;

Shi, Li-Jun ;

Liu, Yong ;

Jiang, Ai-Min ;

Zhao, Li-Li ;

Song, Guang ;

Liu, Tie-Fu .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2012, 51 (05) :705-709

[5] (1->3)-beta-D-glucans as biological response modifiers: A review of structure-functional activity relationships [J].

Bohn, JA ;

BeMiller, JN .

CARBOHYDRATE POLYMERS, 1995, 28 (01) :3-14

[6]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[7] Enhancement of anti-tumor activity of gamma-irradiated silk fibroin via immunomodulatory effects [J].

Byun, Eui-Baek ;

Sung, Nak-Yun ;

Kim, Jae-Hun ;

Choi, Jong-il ;

Matsui, Toshiro ;

Byun, Myung-Woo ;

Lee, Ju-Woon .

CHEMICO-BIOLOGICAL INTERACTIONS, 2010, 186 (01) :90-95

[8]

Cai P., 2001, Lishizhen Medicine and Materia Medica Research, V12, P1137

[9] Anti-tumor and immunomodulating activities of a polysaccharide from the root of Sanguisorba officinalis L. [J].

Cai, Zibin ;

Li, Wei ;

Wang, Haotian ;

Yan, Weiqun ;

Zhou, Yulai ;

Wang, Guanjun ;

Cui, Jiuwei ;

Wang, Fang .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2012, 51 (04) :484-488

[10] Purification, antitumour and immunomodulatory activity of water-extractable and alkali-extractable polysaccharides from Solanurn nigrum L. [J].

Ding, Xia ;

Zhu, Fangshi ;

Gao, Siguo .

FOOD CHEMISTRY, 2012, 131 (02) :677-684

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