Multisite phosphorylation and the countdown to S phase

被引：114

作者：

Deshaies, RJ ^{[1
]}

Ferrell, JE

机构：

[1] Stanford Univ, Sch Med, Dept Mol Pharmacol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA

[3] CALTECH, Div Biol, Pasadena, CA 91125 USA

[4] CALTECH, Howard Hughes Med Inst, Pasadena, CA 91125 USA

来源：

CELL | 2001年 / 107卷 / 07期

关键词：

D O I：

10.1016/S0092-8674(01)00620-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Remarkably, SCFCdc4 ubiquitin ligase binds and ubiquitinates Sic1 decorated with six, but not five, phosphates (Nash et al., 2001). This numerical wizardry suggests how analog inputs can be rectified to digital outputs. Unraveling the counting mechanism promises to generate new insights into the architecture of protein nanoprocessors.

引用

页码：819 / 822

页数：4

共 20 条

[1] A multidimensional electrospray MS-based approach to phosphopeptide mapping
Annan, RS
Huddleston, MJ
Verma, R
Deshaies, RJ
Carr, SA
[J]. ANALYTICAL CHEMISTRY, 2001, 73 (03) : 393 - 404
[2] Phosphorylation and proteolysis: Partners in the regulation of cell division in budding yeast
Deshaies, RJ
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1997, 7 (01) : 7 - 16
[3] A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p
Feldman, RMR
Correll, CC
Kaplan, KB
Deshaies, RJ
[J]. CELL, 1997, 91 (02) : 221 - 230
[4] How responses get more switch like as you move dawn a protein kinase cascade
Ferrell, JE
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (08) : 288 - 289
[5] The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes
Ferrell, JE
Machleder, EM
[J]. SCIENCE, 1998, 280 (5365) : 895 - 898
[6] Ultrasensitivity in the mitogen-activated protein kinase cascade
Huang, CYF
Ferrell, JE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (19) : 10078 - 10083
[7] Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase
Koepp, DM
Schaefer, LK
Ye, X
Keyomarsi, K
Chu, C
Harper, JW
Elledge, SJ
[J]. SCIENCE, 2001, 294 (5540) : 173 - 177
[8] Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo-complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase
Kominami, K
Ochotorena, I
Toda, T
[J]. GENES TO CELLS, 1998, 3 (11) : 721 - 735
[9] Function of WW domains as phosphoserine- or phosphothreonine-binding modules
Lu, PJ
Zhou, XZ
Shen, MH
Lu, KP
[J]. SCIENCE, 1999, 283 (5406) : 1325 - 1328
[10] Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines
Moberg, KH
Bell, DW
Wahrer, DCR
Haber, DA
Hariharan, IK
[J]. NATURE, 2001, 413 (6853) : 311 - 316

← 1 2 →