Size-based protein separations in poly(ethylene glycol)-derivatized gold nanotubule membranes

被引：132

作者：

Yu, SF ^{[1
]}

Lee, SB ^{[1
]}

Kang, M ^{[1
]}

Martin, CR ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

来源：

NANO LETTERS | 2001年 / 1卷 / 09期

关键词：

D O I：

10.1021/nl010044l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An electroless plating method was used to deposit Au nanotubules within the pores of track-etched polycarbonate template membranes. The effect of nanotubule inside diameter on rate and selectivity of protein transport was investigated for three proteins: lysozyme (Lys), bovine serum albumin (BSA), and beta-lactoglobulin A. Transport selectivity increased as the inside diameter of the nanotubules within the membrane decreased, and selectivity coefficients in excess of 20 were observed for the separation of Lys from BSA. Protein adsorption, and hence membrane fouling, was eliminated by chemisorbing a poly(ethylene glycol) thiol to the Au nanotubule membranes.

引用

页码：495 / 498

页数：4

共 34 条

[1] Resistive-pulse sensing - From microbes to molecules [J].