How useful is ferrocene as a scaffold for the design of β-sheet foldamers?

被引：48

作者：

Chowdhury, Somenath ^{[2
]}

Schatte, Gabriele ^{[3
]}

Kraatz, Heinz-Bernhard ^{[1
]}

机构：

[1] Univ Western Ontario, Dept Chem, 1151 Richmond St, London, ON N6A 5B7, Canada

[2] Univ Saskatchewan, Dept Chem, Saskatoon, SK S7N 5C9, Canada

[3] Univ Saskatchewan, Saskatchewan Struct Sci Ctr, Saskatoon, SK S7N 5C9, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 37期

关键词：

ferrocene; foldamers; molecular scaffolds; peptides; self-assembly;

D O I：

10.1002/anie.200801460

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Crease crossing peptide embossing: The first tripeptide ferrocene foldamers to adopt an extended β-sheet-like structure in solution and solid state are presented. The flexibility of peptide substituents in 1,n′-ferrocene-bispeptide conjugates was thought to prevent the formation of extended β-sheet foldamers. The results suggest that ferrocene is a valuable scaffold for extended β-sheets. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7056 / 7059

页数：4

共 36 条

[1]

[Anonymous], ANGEW CHEM

[2]

Aravinda S, 2002, ANGEW CHEM INT EDIT, V41, P3863, DOI 10.1002/1521-3773(20021018)41:20<3863::AID-ANIE3863>3.0.CO

[3]

2-A

[4]

Aravinda S., 2002, ANGEW CHEM, V114, P4019