Mitochondrial DNA maintenance and bioenergetics

被引：78

作者：

Stuart, JA ^{[1
]}

Brown, MF ^{[1
]}

机构：

[1] Brock Univ, Dept Biol Sci, St Catharines, ON L2S 3A1, Canada

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2006年 / 1757卷 / 02期

基金：

加拿大自然科学与工程研究理事会; 加拿大创新基金会;

关键词：

mtDNA; mitochondria; reactive oxygen species; base excision repair; DNA repair; oxidative phosphorylation;

D O I：

10.1016/j.bbabio.2006.01.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidative phosphorylation requires assembly of the protein products of both mitochondrial and of nuclear genomes into functional respiratory complexes. Cellular respiration can be compromised when mitochondrial DNA (mtDNA) sequences are corrupted. Oxidative damage resulting from reactive oxygen species (ROS) produced during respiration is probably a major source of mitochondrial genomic instability leading to respiratory dysfunction. Here, we review mechanisms of mitochondrial ROS production, mtDNA damage and its relationship to mitochondrial dysfunction. We focus particular attention on the roles of mtDNA repair enzymes and processes by which the integrity of the mitochondrial genome is maintained and dysfunction prevented. (C) 2006 Elsevier B.V. All rights reserved.

引用

页码：79 / 89

页数：11

共 147 条

[11] Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype [J].

Chatterjee, A ;

Singh, KK .

NUCLEIC ACIDS RESEARCH, 2001, 29 (24) :4935-4940

[12] Age-dependent decline of DNA repair activity for oxidative lesions in rat brain mitochondria [J].

Chen, DX ;

Cao, GD ;

Hastings, T ;

Feng, YQ ;

Pei, W ;

O'Horo, C ;

Chen, J .

JOURNAL OF NEUROCHEMISTRY, 2002, 81 (06) :1273-1284

[13]

CHEN YH, 1993, J BIOL CHEM, V268, P5849

[14] Mitochondria isolated from liver contain the essential factors required for RNA/DNA oligonucleotide-targeted gene repair [J].

Chen, ZY ;

Felsheim, R ;

Wong, P ;

Augustin, LB ;

Metz, R ;

Kren, BT ;

Steer, CJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 285 (02) :188-194

[15]

CHI NW, 1994, J BIOL CHEM, V269, P29984

[16] ABSENCE OF A PYRIMIDINE DIMER REPAIR MECHANISM IN MAMMALIAN MITOCHONDRIA [J].

CLAYTON, DA ;

DODA, JN ;

FRIEDBER.EC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (07) :2777-2781

[17] Oxidative DNA damage: mechanisms, mutation, and disease [J].

Cooke, MS ;

Evans, MD ;

Dizdaroglu, M ;

Lunec, J .

FASEB JOURNAL, 2003, 17 (10) :1195-1214

[18] A SINGLE NUCLEOTIDE SUBSTITUTION AT THE RIB2 LOCUS OF THE YEAST MITOCHONDRIAL GENE FOR 21S RIBOSOMAL-RNA CONFERS RESISTANCE TO ERYTHROMYCIN AND COLD-SENSITIVE RIBOSOME ASSEMBLY [J].

CUI, Z ;

MASON, TL .

CURRENT GENETICS, 1989, 16 (04) :273-279

[19] Heterologous mitochondrial DNA recombination in human cells [J].

D'Aurelio, M ;

Gajewski, CD ;

Lin, MT ;

Mauck, WM ;

Shao, LZ ;

Lenaz, G ;

Moraes, CT ;

Manfredi, G .

HUMAN MOLECULAR GENETICS, 2004, 13 (24) :3171-3179

[20] Proteomic analysis of the mouse liver mitochondrial inner membrane [J].

Da Cruz, S ;

Xenarios, I ;

Langridge, J ;

Vilbois, F ;

Parone, PA ;

Martinou, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (42) :41566-41571

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