Interaction of fumonisin B1 and aflatoxin B1 in a short-term carcinogenesis model in rat liver

被引:82
作者
Gelderblom, WCA
Marasas, WFO
Lebepe-Mazur, S
Swanevelder, S
Vessey, CJ
Hall, PD
机构
[1] MRC, PROMEC Unit, ZA-7505 Tygerberg, South Africa
[2] MRC, Biostat Unit, ZA-7505 Tygerberg, South Africa
[3] Univ Cape Town, Fac Hlth Sci, Dept Anat Pathol, ZA-7925 Cape Town, South Africa
关键词
fumonisin B-1; alatoxin B-1; rat liver;
D O I
10.1016/S0300-483X(01)00573-X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The co-existence of the fumonisin and aflatoxin mycotoxins in corn merited studies to investigate their possible synergistic toxicological and carcinogenic effects. When utilising a short-term carcinogenesis model in rat liver, both the compounds exhibited slow cancer initiating potency as monitored by the induction of foci and nodules stained positively for the placental form of gluthatione-S-transferase (GSTP(+)). However, when rats were treated in a sequential manner with AFB(1) and FB1 the number and size of GSTP(+) lesions significantly increased as compared to the separate treatments. Histopathological analyses indicated that the individual treatments showed far less toxic effects, including occasional hepatocytes with dysplastic nuclei, oval cell proliferation and, in the case of FBI, a few apoptotic bodies in the central vein regions. The sequential treatment regimen induced numerous foci and dysplastic hepatocyte nodules, and with oval cells extending from the periportal regions into the centrilobular regions. This would imply that, in addition to the cancer promoting activity of FBI of AFB(1)-initiated hepatocytes, the AFB(1) pre-treatment enhanced the FBI initiating potency, presumably by rendering the liver more susceptible to the toxic effects of FBI. The co-occurrence of AFB(1) and FB1 in corn consumed as a staple diet could pose an increased risk and should be included in establishing risk assessment parameters in humans. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:161 / 173
页数:13
相关论文
共 55 条
[1]   Cytotoxicity of fumonisin B1:: implication of lipid peroxidation and inhibition of protein and DNA syntheses [J].
Abado-Becognee, K ;
Mobio, TA ;
Ennamany, R ;
Fleurat-Lessard, F ;
Shier, WT ;
Badria, F ;
Creppy, EE .
ARCHIVES OF TOXICOLOGY, 1998, 72 (04) :233-236
[2]   Oxidative damage and fumonisin B1-induced toxicity in primary rat hepatocytes and rat liver in vivo [J].
Abel, S ;
Gelderblom, WCA .
TOXICOLOGY, 1998, 131 (2-3) :121-131
[3]  
Ali N, 1998, FOOD ADDIT CONTAM, V15, P377, DOI 10.1080/02652039809374655
[4]  
*AM I NUTR, 1980, J NUTR, V110, P1726
[5]   KERATIN-14 PROTEIN IN CULTURED NONPARENCHYMAL RAT HEPATIC EPITHELIAL-CELLS - CHARACTERIZATION OF KERATIN-14 AND KERATIN-19 AS ANTIGENS FOR THE COMMONLY USED MOUSE MONOCLONAL-ANTIBODY OV-6 [J].
BISGAARD, HC ;
PARMELEE, DC ;
DUNSFORD, HA ;
SECHI, S ;
THORGEIRSSON, SS .
MOLECULAR CARCINOGENESIS, 1993, 7 (01) :60-66
[6]   Fumonisin B1 promotes aflatoxin B1 and N-methyl-N′-nitro-nitrosoguanidine-initiated liver tumors in rainbow trout [J].
Carlson, DB ;
Williams, DE ;
Spitsbergen, JM ;
Ross, PF ;
Bacon, CW ;
Meredith, FI ;
Riley, RT .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2001, 172 (01) :29-36
[7]   Human health and chemical mixtures: An overview [J].
Carpenter, DO ;
Arcaro, KF ;
Bush, B ;
Niemi, WD ;
Pang, SK ;
Vakharia, DD .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1998, 106 :1263-1270
[8]   ISOLATION OF THE FUMONISIN MYCOTOXINS - A QUANTITATIVE APPROACH [J].
CAWOOD, ME ;
GELDERBLOM, WCA ;
VLEGGAAR, R ;
BEHREND, Y ;
THIEL, PG ;
MARASAS, WFO .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1991, 39 (11) :1958-1962
[9]   SIMULTANEOUS OCCURRENCE OF FUMONISIN B-1 AND OTHER MYCOTOXINS IN MOLDY CORN COLLECTED FROM THE PEOPLES-REPUBLIC-OF-CHINA IN REGIONS WITH HIGH INCIDENCES OF ESOPHAGEAL CANCER [J].
CHU, FS ;
LI, GY .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1994, 60 (03) :847-852
[10]  
COLUMBANO A, 1981, CANCER RES, V41, P2079