A Periodic Table of Coiled-Coil Protein Structures

被引：147

作者：

Moutevelis, Efrosini ^{[1
]}

Woolfson, Derek N. ^{[1
,2
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2009年 / 385卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

alpha-helix; coiled coil; knob-into-hole interaction; protein structure classification; periodic table; CRYSTAL-STRUCTURE; MULTIDRUG EFFLUX; CLASSIFICATION; DATABASE; RESTRICTIONS; POLYPEPTIDE; FAMILIES; PROGRAM; PACKING; MOTIFS;

D O I：

10.1016/j.jmb.2008.11.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Coiled coils are protein structure domains with two or more alpha-hetices packed together via interlacing of side chains known as knob-into-hole packing. We analysed and classified a large set of coiled-coil structures using a combination of automated and manual methods. This led to a systematic classification that we termed a "periodic table of coiled coils," which we have made available at http://coiledcoils.chm.bris.ac.uk/ccplus/search/periodic-table. In this table, coiled-coil assemblies are arranged in columns with increasing numbers of alpha-helices and in rows of increased complexity. The table provides a framework for understanding possibilities in and limits on coiled-coil structures and a basis for future prediction, engineering and design studies. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：726 / 732

页数：7

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