Effects of Puerariae radix on cell proliferation and nitric oxide synthase expression in dentate gyrus of alcohol-intoxicated Sprague-Dawley rats

被引：4

作者：

Jang, MH

Shin, MC

Chung, JH

Shin, HD

Kim, Y

Kim, EH

Kim, CJ

机构：

[1] Kyung Hee Univ, Coll Med, Dept Physiol, Dongdaemun Gu, Seoul 130701, South Korea

[2] Kyung Hee Univ, Coll Med, Dept Pharmacol, Dongdaemun Gu, Seoul 130701, South Korea

[3] Kyung Hee Univ, Coll Oriental Med, Dept Oriental Rehabil Med, Seoul, South Korea

[4] Semyung Univ, Coll Oriental Med, Dept Biochem, Chungbuk, South Korea

[5] Semyung Univ, Coll Oriental Med, Dept Meridianol, Chungbuk, South Korea

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 2002年 / 88卷 / 03期

关键词：

Puerariae radix; alcohol; immunohistochemistry;

D O I：

10.1254/jjp.88.355

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Traditionally, Puerariae radix had been used for the treatment of alcohol-related problems. In this study, effects of Puerariae radix on cell proliferation and nitric oxide synthase expression in the dentate gyrus of alcohol-intoxicated Sprague-Dawley rats were investigated via 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Alcohol administration was shown to inhibit the numbers of both BrdU-positive and NADPH-d-positive cells, while Puerariae radix treatment was shown to increase those numbers. It is possible that nitric oxide, which might play an important role in the regulation of cell proliferation, is a major target of the toxic effects of alcohol.

引用

页码：355 / 358

页数：4

共 15 条

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