Sirt1 Def-eating senescence?

被引：68

作者：

Fusco, Salvatore ^{[2
]}

Maulucci, Giuseppe ^{[1
]}

Pani, Giovambattista ^{[2
]}

机构：

[1] Univ Cattolica Sacro Cuore, Sch Med, Inst Phys, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Sch Med, Inst Gen Pathol, I-00168 Rome, Italy

来源：

CELL CYCLE | 2012年 / 11卷 / 22期

关键词：

Sirt1; nutrient signaling; calorie restriction; aging; metabolic disease; CR; REPLICATIVE LIFE-SPAN; FATTY-ACID OXIDATION; CALORIE RESTRICTION; CELL-SURVIVAL; REGULATES SIRT1; SKELETAL-MUSCLE; MITOCHONDRIAL-FUNCTION; DEACETYLASE ACTIVITY; INSULIN SENSITIVITY; ACTIVATING SIRT1;

D O I：

10.4161/cc.22074

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Sirt1, the closest mammalian homolog of the Sir2 yeast longevity protein, has been extensively investigated in the last few years as an avenue to understand the connection linking nutrients and energy metabolism with aging and related diseases. From this research effort the picture has emerged of an enzyme at the hub of a complex array of molecular interactions whereby nutrient-triggered signals are translated into several levels of adaptive cell responses, the failure of which underlies diseases as diverse as diabetes, neurodegeneration and cancer. Sirt1 thus connects moderate calorie intake to "healthspan," and a decline of Sirt-centered protective circuits over time may explain the "catastrophic" nature of aging.

引用

页码：4135 / 4146

页数：12

共 140 条

[21]

Tissue-specific regulation of SIRT1 by calorie restriction [J].

Chen, Danica ;

Bruno, Joanne ;

Easlon, Erin ;

Lin, Su-Ju ;

Cheng, Hwei-Ling ;

Alt, Frederick W. ;

Guarente, Leonard .

GENES & DEVELOPMENT, 2008, 22 (13) :1753-1757

[22]

Hypoxia Increases Sirtuin 1 Expression in a Hypoxia-inducible Factor-dependent Manner [J].

Chen, Rui ;

Dioum, Elhadji M. ;

Hogg, Richard T. ;

Gerard, Robert D. ;

Garcia, Joseph A. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (16) :13869-13878

[23]

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses [J].

Chen, WY ;

Wang, DH ;

Yen, RWC ;

Luo, JY ;

Gu, W ;

Baylin, SB .

CELL, 2005, 123 (03) :437-448

[24]

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice [J].

Cheng, HL ;

Mostoslavsky, R ;

Saito, S ;

Manis, JP ;

Gu, YS ;

Patel, P ;

Bronson, R ;

Appella, E ;

Alt, FW ;

Chua, KF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) :10794-10799

[25]

Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress [J].

Chua, KF ;

Mostoslavsky, R ;

Lombard, DB ;

Pang, WW ;

Saito, S ;

Franco, S ;

Kaushal, D ;

Cheng, HL ;

Fischer, MR ;

Stokes, N ;

Murphy, MM ;

Appella, E ;

Alt, FW .

CELL METABOLISM, 2005, 2 (01) :67-76

[26]

Using PDE inhibitors to harness the benefits of calorie restriction: lessons from resveratrol [J].

Chung, Jay H. .

AGING-US, 2012, 4 (03) :144-145

[27]

Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction [J].

Cohen, Dena E. ;

Supinski, Andrea M. ;

Bonkowski, Michael S. ;

Donmez, Gizem ;

Guarente, Leonard P. .

GENES & DEVELOPMENT, 2009, 23 (24) :2812-2817

[28]

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase [J].

Cohen, HY ;

Miller, C ;

Bitterman, KJ ;

Wall, NR ;

Hekking, B ;

Kessler, B ;

Howitz, KT ;

Gorospe, M ;

de Cabo, R ;

Sinclair, DA .

SCIENCE, 2004, 305 (5682) :390-392

[29]

The role of transcriptional regulators in central control of appetite and body weight [J].

Coppari, Roberto ;

Ramadori, Giorgio ;

Elmquist, Joel K. .

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM, 2009, 5 (03) :160-166

[30]

Histone H4 lysine 16 acetylation regulates cellular lifespan [J].

Dang, Weiwei ;

Steffen, Kristan K. ;

Perry, Rocco ;

Dorsey, Jean A. ;

Johnson, F. Brad ;

Shilatifard, Ali ;

Kaeberlein, Matt ;

Kennedy, Brian K. ;

Berger, Shelley L. .

NATURE, 2009, 459 (7248) :802-U2

← 1 2 3 4 5 6 7 8 9 10 →