Cytokine genetic profile in Whipple's disease

被引：26

作者：

Biagi, F. ^{[1
,2
]}

Badulli, C. ^{[3
]}

Feurle, G. E. ^{[4
]}

Mueller, C. ^{[5
]}

Moos, V. ^{[6
]}

Schneider, T. ^{[6
]}

Marth, T. ^{[7
]}

Mytilineos, J. ^{[8
]}

Garlaschelli, F. ^{[3
]}

Marchese, A. ^{[2
]}

Trotta, L. ^{[2
]}

Bianchi, P. I. ^{[2
]}

Di Stefano, M. ^{[2
]}

Cremaschi, A. L. ^{[3
]}

De Silvestri, A.

Salvaneschi, L. ^{[3
]}

Martinetti, M. ^{[3
]}

Corazza, G. R. ^{[2
]}

机构：

[1] Fdn IRCCS Policlin San Matteo, Coeliac Ctr, Dept Internal Med 1, I-27100 Pavia, Italy

[2] Univ Pavia, IRCCS Fdn Policlin San Matteo, Dept Internal Med 1, I-27100 Pavia, Italy

[3] IRCCS Fdn Policlin San Matteo, Immunohematol & Transfus Ctr, I-27100 Pavia, Italy

[4] DRK Krankenhaus, Neuwied, Germany

[5] Med Univ Wien, Klin Abt Gastroenterol & Hepatol, Univ Klin Innere Med 3, Vienna, Austria

[6] Charite, CBF, Med Klin 1, D-13353 Berlin, Germany

[7] Krankenhaus Maria Hilf, Innere Med Abt, Daun, Germany

[8] Univ Heidelberg, Inst Immunol, Dept Transplantat Immunol, D-6900 Heidelberg, Germany

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2012年 / 31卷 / 11期

关键词：

REGULATORY T-CELLS; TROPHERYMA-WHIPPLEI; MACROPHAGES; DIAGNOSIS; PAIR;

D O I：

10.1007/s10096-012-1677-8

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

Whipple's disease (WD) is a very rare chronic systemic condition characterised by a Th2/T regulatory (Treg) dysregulated immune response versus Tropheryma whipplei, a bacterium widely diffuse in the environment. To investigate whether this Th2/Treg polarised response has a genetic background, we investigated the Th1, Th2, Th17 and Treg cytokine genetic profile of 133 patients with WD. Thanks to the European Consortium on WD (QLG1-CT-2002-01049), the polymorphism of 13 cytokine genes was analysed in 111 German and 22 Italian patients using the polymerase chain reaction with sequence-specific primers (PCR-SSP) technique. The frequencies of the genotypes, haplotypes and functional phenotypes were compared with those obtained in 201 German and 140 Italian controls. Clinical heterogeneity was also considered. Functionally, WD patients may be considered as low producers of TGF-beta 1, having an increased frequency of the genotype TGF-beta 1+869C/C,+915C/C [12.3 % vs. 3.81 %, odds ratio (OR) = 4.131, p = 0.0002] and high secretors of IL-4, carrying the genotype IL-4-590T/T (5.34 % vs. 1.17 %, OR = 5.09, p = 0.0096). No significant association was found between cytokine polymorphism and clinical variability. Analogously to the recent cellular findings of a Th2/Treg polarised response, we showed that the cytokine genetic profile of WD patients is skewed toward a Th2 and Treg response. This was similar in both German and Italian populations. However, the significant deviations versus the controls are poorer than that expected on the basis of these recent cellular findings.

引用

页码：3145 / 3150

页数：6

共 30 条

[1]

Macrophage polarization in bacterial infections [J].