Whipple disease: intestinal infiltrating cells exhibit a transcriptional pattern of M2/alternatively activated macrophages

被引：64

作者：

Desnues, B ^{[1
]}

Lepidi, H ^{[1
]}

Raoult, D ^{[1
]}

Mege, JL ^{[1
]}

机构：

[1] Univ Mediterranee, Fac Med, Inst Federat Rech 48, Unite Rickettsies,CNRS,UMR 6020, F-13385 Marseille, France

来源：

JOURNAL OF INFECTIOUS DISEASES | 2005年 / 192卷 / 09期

关键词：

D O I：

10.1086/491745

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Whipple disease (WD) is a rare systemic disease caused by Tropheryma whipplei and is characterized by the presence of foamy macrophages with periodic acid-Schiff - positive inclusions in tissues such as lamina propria. For the first time, we report the gene-expression profile of macrophages in intestinal lesions from a patient with WD. Microarray and real-time polymerase chain reaction revealed that genes encoding CCL18, cathepsins, scavenger receptor, interleukin-10, and lipid metabolites were up-regulated in intestinal lesions. This transcriptional pattern corresponds to that of M2/alternatively activated macrophages. Our results suggest that the T helper 2 response in the intestinal environment may account for the pathophysiological properties of WD.

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页码：1642 / 1646

页数：5

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