The interleukin-1β +3953 single nucleotide polymorphism:: Cervical protein concentration and preterm delivery risk

Problem To determine the associations between preterm delivery < 37 weeks (PTD), cervical fluid interleukin-1 beta (IL-1 beta) concentration, and its +3953 single nucleotide polymorphism (SNP). Method of Study Cervical fluid, peripheral blood, and cord blood samples were obtained from a cohort of women 23-32 weeks gestation with preterm labor symptoms and intact membranes. Results Increased cervical fluid concentrations of IL-1 beta were associated with PTD (P = 0.017) and spontaneous PTD (P = 0.001). Maternal IL-1 beta +3953 SNP genotype was associated neither with PTD (P = 0.43) nor with cervical fluid IL-1 beta concentrations (P = 0.35). Neonatal IL-1 beta +3953 SNP genotype was associated neither with PTD nor cervical IL-1 beta concentrations. Conclusion Cervical fluid concentrations of IL-1 beta were elevated in symptomatic women destined to have a spontaneous PTD. The gene dosage of maternal IL-1 beta +3953 allele 2 was associated neither with increased cervical fluid concentrations of IL-1 beta nor with risk of PTD.