The interleukin-1β +3953 single nucleotide polymorphism:: Cervical protein concentration and preterm delivery risk

被引：22

作者：

Edwards, RK ^{[1
]}

Ferguson, RJ ^{[1
]}

Duff, P ^{[1
]}

机构：

[1] Univ Florida, Coll Med, Dept Obstet & Gynecol, Gainesville, FL 32610 USA

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2006年 / 55卷 / 04期

关键词：

cervical fluid; interleukin-1; beta; preterm delivery; single nucleotide polymorphism;

D O I：

10.1111/j.1600-0897.2005.00358.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Problem To determine the associations between preterm delivery < 37 weeks (PTD), cervical fluid interleukin-1 beta (IL-1 beta) concentration, and its +3953 single nucleotide polymorphism (SNP). Method of Study Cervical fluid, peripheral blood, and cord blood samples were obtained from a cohort of women 23-32 weeks gestation with preterm labor symptoms and intact membranes. Results Increased cervical fluid concentrations of IL-1 beta were associated with PTD (P = 0.017) and spontaneous PTD (P = 0.001). Maternal IL-1 beta +3953 SNP genotype was associated neither with PTD (P = 0.43) nor with cervical fluid IL-1 beta concentrations (P = 0.35). Neonatal IL-1 beta +3953 SNP genotype was associated neither with PTD nor cervical IL-1 beta concentrations. Conclusion Cervical fluid concentrations of IL-1 beta were elevated in symptomatic women destined to have a spontaneous PTD. The gene dosage of maternal IL-1 beta +3953 allele 2 was associated neither with increased cervical fluid concentrations of IL-1 beta nor with risk of PTD.

引用

页码：259 / 264

页数：6

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