The stress of finding NEMO

被引:20
作者
Bartek, J
Lukas, J
机构
[1] Danish Canc Soc, Inst Canc Biol, DK-2100 Copenhagen, Denmark
[2] Danish Canc Soc, Ctr Genotox Stress Res, DK-2100 Copenhagen, Denmark
关键词
D O I
10.1126/science.1124540
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A cell's response to damaged DNA is triggered when two proteins leave the nucleus and converge upon a signaling complex in the cytoplasm. This activates a key transcription factor that then moves into the nucleus to promote cell survival.
引用
收藏
页码:1110 / 1111
页数:2
相关论文
共 15 条
  • [1] DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    Bartkova, J
    Horejsi, Z
    Koed, K
    Krämer, A
    Tort, F
    Zieger, K
    Guldberg, P
    Sehested, M
    Nesland, JM
    Lukas, C
    Orntoft, T
    Lukas, J
    Bartek, J
    [J]. NATURE, 2005, 434 (7035) : 864 - 870
  • [2] Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    Gorgoulis, VG
    Vassiliou, LVF
    Karakaidos, P
    Zacharatos, P
    Kotsinas, A
    Liloglou, T
    Venere, M
    DiTullio, RA
    Kastrinakis, NG
    Levy, B
    Kletsas, D
    Yoneta, A
    Herlyn, M
    Kittas, C
    Halazonetis, TD
    [J]. NATURE, 2005, 434 (7035) : 907 - 913
  • [3] SUMO: A history of modification
    Hay, RT
    [J]. MOLECULAR CELL, 2005, 18 (01) : 1 - 12
  • [4] Signaling to NF-κB
    Hayden, MS
    Ghosh, S
    [J]. GENES & DEVELOPMENT, 2004, 18 (18) : 2195 - 2224
  • [5] Sequential modification of NEMO/IKKγ by SUMO-1 and ubiquitin mediates NF-κB activation by genotoxic stress
    Huang, TT
    Wuerzbrger-Davis, SM
    Wu, ZH
    Miyamoto, S
    [J]. CELL, 2003, 115 (05) : 565 - 576
  • [6] PIDD mediates NF-κB activation in response to DNA damage
    Janssens, S
    Tinel, A
    Lippens, S
    Tschopp, J
    [J]. CELL, 2005, 123 (06) : 1079 - 1092
  • [7] Proapoptotic BID is an ATM effector in the DNA-damage response
    Kamer, I
    Sarig, R
    Zaltsman, Y
    Niv, H
    Oberkovitz, G
    Regev, L
    Haimovich, G
    Lerenthal, Y
    Marcellus, RC
    Gross, A
    [J]. CELL, 2005, 122 (04) : 593 - 603
  • [8] NF-κB in cancer:: From innocent bystander to major culprit
    Karin, M
    Cao, YX
    Greten, FR
    Li, ZW
    [J]. NATURE REVIEWS CANCER, 2002, 2 (04) : 301 - 310
  • [9] The IKKNF-κB system:: A treasure trove for drug development
    Karin, M
    Yamamoto, Y
    Wang, QM
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (01) : 17 - 26
  • [10] Cell-cycle checkpoints and cancer
    Kastan, MB
    Bartek, J
    [J]. NATURE, 2004, 432 (7015) : 316 - 323